Kyle R Hager
Overview
Explore the profile of Kyle R Hager including associated specialties, affiliations and a list of published articles.
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13
Citations
525
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0
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Recent Articles
1.
Eng A, Hayden H, Pope C, Brittnacher M, Vo A, Weiss E, et al.
BMC Microbiol
. 2021 Sep;
21(1):247.
PMID: 34525965
Background: Infants with cystic fibrosis (CF) suffer from gastrointestinal (GI) complications, including pancreatic insufficiency and intestinal inflammation, which have been associated with impaired nutrition and growth. Recent evidence identified altered...
2.
Meeker S, Mears K, Sangwan N, Brittnacher M, Weiss E, Treuting P, et al.
PLoS Pathog
. 2020 Jan;
16(1):e1008251.
PMID: 31961914
Patients with cystic fibrosis (CF) have altered fecal microbiomes compared to those of healthy controls. The magnitude of this dysbiosis correlates with measures of CF gastrointestinal (GI) disease, including GI...
3.
Hayden H, Eng A, Pope C, Brittnacher M, Vo A, Weiss E, et al.
Nat Med
. 2020 Jan;
26(2):215-221.
PMID: 31959989
Most infants with cystic fibrosis (CF) have pancreatic exocrine insufficiency that results in nutrient malabsorption and requires oral pancreatic enzyme replacement. Newborn screening for CF has enabled earlier diagnosis, nutritional...
4.
Nelson M, Pope C, Marsh R, Wolter D, Weiss E, Hager K, et al.
Cell Rep
. 2019 Feb;
26(8):2227-2240.e5.
PMID: 30784601
Metagenomic sequencing is a promising approach for identifying and characterizing organisms and their functional characteristics in complex, polymicrobial infections, such as airway infections in people with cystic fibrosis. These analyses...
5.
Adaptation of commensal proliferating to the intestinal tract of young children with cystic fibrosis
Matamouros S, Hayden H, Hager K, Brittnacher M, Lachance K, Weiss E, et al.
Proc Natl Acad Sci U S A
. 2018 Jan;
115(7):1605-1610.
PMID: 29378945
The mature human gut microbiota is established during the first years of life, and altered intestinal microbiomes have been associated with several human health disorders. usually represents less than 1%...
6.
Akullian A, Montgomery J, John-Stewart G, Miller S, Hayden H, Radey M, et al.
PLoS Negl Trop Dis
. 2018 Jan;
12(1):e0006156.
PMID: 29329299
Non-typhoidal Salmonella (NTS) is a leading cause of bloodstream infections in Africa, but the various contributions of host susceptibility versus unique pathogen virulence factors are unclear. We used data from...
7.
Hayden H, Matamouros S, Hager K, Brittnacher M, Rohmer L, Radey M, et al.
mBio
. 2016 Mar;
7(2):e00154.
PMID: 26956590
Unlabelled: Salmonella enterica serovar Typhimurium is one of the most common S. enterica serovars associated with U.S. foodborne outbreaks. S. Typhimurium bacteria isolated from humans exhibit wide-ranging virulence phenotypes in...
8.
Manor O, Levy R, Pope C, Hayden H, Brittnacher M, Carr R, et al.
Sci Rep
. 2016 Mar;
6:22493.
PMID: 26940651
Cystic fibrosis (CF) results in inflammation, malabsorption of fats and other nutrients, and obstruction in the gastrointestinal (GI) tract, yet the mechanisms linking these disease manifestations to microbiome composition remain...
9.
Damman C, Brittnacher M, Westerhoff M, Hayden H, Radey M, Hager K, et al.
PLoS One
. 2015 Aug;
10(8):e0133925.
PMID: 26288277
Objective: Fecal microbiota transplantation (FMT) is an investigational treatment for diseases thought to involve alterations in the intestinal microbiota including ulcerative colitis (UC). Case reports have described therapeutic benefit of...
10.
Matamouros S, Hager K, Miller S
mBio
. 2015 May;
6(3):e00616-15.
PMID: 26015499
Unlabelled: HAMP domains are α-helical coiled coils that often transduce signals from extracytoplasmic sensing domains to cytoplasmic domains. Limited structural information has resulted in hypotheses that specific HAMP helix movement...