Christopher E Hart
Overview
Explore the profile of Christopher E Hart including associated specialties, affiliations and a list of published articles.
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15
Citations
523
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0
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Recent Articles
1.
Mignon L, Doan K, Murphy M, Elder L, Yun C, Milton J, et al.
Contemp Clin Trials
. 2022 Jun;
119:106819.
PMID: 35691489
Background: Pharmaceutical drug development rarely addresses a study participant's control of their genomic data, how to return individual incidental findings, and how to make use of genomic data more efficiently...
2.
Carrer M, Crosby J, Sun G, Zhao C, Damle S, Kuntz S, et al.
Am J Respir Cell Mol Biol
. 2020 Mar;
63(1):46-56.
PMID: 32176858
Goblet cell metaplasia, excessive mucus production, and inadequate mucus clearance accompany and exacerbate multiple chronic respiratory disorders, such as asthma and chronic obstructive pulmonary disease. Notch signaling plays a central...
3.
Aghajan M, Booten S, Althage M, Hart C, Ericsson A, Maxvall I, et al.
JCI Insight
. 2019 Jun;
4(12).
PMID: 31217349
African Americans develop end-stage renal disease at a higher rate compared with European Americans due to 2 polymorphisms (G1 and G2 risk variants) in the apolipoprotein L1 (APOL1) gene common...
4.
Shen W, De Hoyos C, Migawa M, Vickers T, Sun H, Low A, et al.
Nat Biotechnol
. 2019 May;
37(6):640-650.
PMID: 31036929
The molecular mechanisms of toxicity of chemically modified phosphorothioate antisense oligonucleotides (PS-ASOs) are not fully understood. Here, we report that toxic gapmer PS-ASOs containing modifications such as constrained ethyl (cEt),...
5.
Cho C, Damle S, Wancewicz E, Mukhopadhyay S, Hart C, Mazur C, et al.
BMC Genomics
. 2019 Mar;
20(1):164.
PMID: 30819113
Background: Microglia are multifunctional cells that are key players in brain development and homeostasis. Recent years have seen tremendous growth in our understanding of the role microglia play in neurodegeneration,...
6.
Crooke S, Baker B, Kwoh T, Cheng W, Schulz D, Xia S, et al.
Mol Ther
. 2016 Jul;
24(10):1771-1782.
PMID: 27357629
The common chemical and biological properties of antisense oligonucleotides provide the opportunity to identify and characterize chemical class effects across species. The chemical class that has proven to be the...
7.
Lima W, Murray H, Damle S, Hart C, Hung G, De Hoyos C, et al.
Nucleic Acids Res
. 2016 May;
44(11):5299-312.
PMID: 27131367
Viable constitutive and tamoxifen inducible liver-specific RNase H1 knockout mice that expressed no RNase H1 activity in hepatocytes showed increased R-loop levels and reduced mitochondrial encoded DNA and mRNA levels,...
8.
Burel S, Hart C, Cauntay P, Hsiao J, Machemer T, Katz M, et al.
Nucleic Acids Res
. 2015 Nov;
44(5):2093-109.
PMID: 26553810
High affinity antisense oligonucleotides (ASOs) containing bicylic modifications (BNA) such as locked nucleic acid (LNA) designed to induce target RNA cleavage have been shown to have enhanced potency along with...
9.
Huang L, Damle S, Booten S, Singh P, Sabripour M, Hsu J, et al.
PLoS One
. 2015 Jul;
10(7):e0132798.
PMID: 26207833
Liver regeneration after partial hepatectomy (PHx) is a complex and well-orchestrated biological process in which synchronized cell proliferation is induced in response to the loss of liver mass. To define...
10.
Wan W, Migawa M, Vasquez G, Murray H, Nichols J, Gaus H, et al.
Nucleic Acids Res
. 2014 Nov;
42(22):13456-68.
PMID: 25398895
Bicyclic oxazaphospholidine monomers were used to prepare a series of phosphorothioate (PS)-modified gapmer antisense oligonucleotides (ASOs) with control of the chirality of each of the PS linkages within the 10-base...