Christopher E Brightling
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Explore the profile of Christopher E Brightling including associated specialties, affiliations and a list of published articles.
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263
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Recent Articles
11.
Leavy O, Russell R, Harrison E, Lone N, Kerr S, Docherty A, et al.
ERJ Open Res
. 2024 Oct;
10(5).
PMID: 39351379
Background: In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administration during...
12.
Wechsler M, Brusselle G, Virchow J, Bourdin A, Kostikas K, Llanos J, et al.
Eur Respir J
. 2024 Sep;
64(6).
PMID: 39326921
Background: In asthma, clinical response is characterised by disease improvement with treatment, whereas clinical remission is characterised by long-term disease stabilisation with or without ongoing treatment. The proportions of patients...
13.
Samat A, Cassar M, Akhtar A, McCracken C, Ashkir Z, Mills R, et al.
Int J Cardiol
. 2024 Aug;
415:132415.
PMID: 39127146
Background: The role of ECG in ruling out myocardial complications on cardiac magnetic resonance (CMR) is unclear. We examined the clinical utility of ECG in screening for cardiac abnormalities on...
14.
Howell I, Yang F, Brown V, Cane J, Marchi E, Azim A, et al.
J Allergy Clin Immunol
. 2024 Aug;
154(5):1146-1158.
PMID: 39097197
Background: Mepolizumab is an anti-IL-5 mAb treatment for severe eosinophilic asthma that reduces asthma exacerbations. Residual airway inflammation with mepolizumab therapy may lead to persistent exacerbations. Oral corticosteroids remain the...
15.
Taquet M, Skorniewska Z, De Deyn T, Hampshire A, Trender W, Hellyer P, et al.
Lancet Psychiatry
. 2024 Aug;
11(9):696-708.
PMID: 39096931
Background: COVID-19 is known to be associated with increased risks of cognitive and psychiatric outcomes after the acute phase of disease. We aimed to assess whether these symptoms can emerge...
16.
Reddy S, Newman J, Leavy O, Ghani H, Pepke-Zaba J, Cannon J, et al.
Eur Respir J
. 2024 Jul;
64(2.
PMID: 39060016
Background: Pulmonary embolism (PE) is a well-recognised complication of coronavirus disease 2019 (COVID-19) infection, and chronic thromboembolic pulmonary disease with and without pulmonary hypertension (CTEPD/CTEPH) are potential life-limiting consequences. At...
17.
Gupta A, Nicholas R, McGing J, Nixon A, Mallinson J, McKeever T, et al.
Exp Physiol
. 2024 Jun;
109(8):1274-1291.
PMID: 38923603
We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular...
18.
Schuermans A, Verstraete A, Lammi V, Nakanishi T, Ardissino M, Van den Eynde J, et al.
medRxiv
. 2024 May;
PMID: 38798608
SARS-CoV-2 infection can result in long COVID, characterized by post-acute symptoms from multiple organs. Current hypotheses on mechanisms underlying long COVID include persistent inflammation and thromboembolism; however, compelling evidence from...
19.
Brightling C, Caminati M, Llanos J, Caveney S, Kotalik A, Griffiths J, et al.
Ann Allergy Asthma Immunol
. 2024 May;
133(3):310-317.e4.
PMID: 38697286
Background: Long-term tezepelumab treatment in the DESTINATION study (NCT03706079) resulted in reduced asthma exacerbations, reduced biomarker levels, and improved lung function and symptom control in patients with severe, uncontrolled asthma....
20.
Varricchi G, Brightling C, Grainge C, Lambrecht B, Chanez P
Eur Respir J
. 2024 Apr;
63(4).
PMID: 38609094
Asthma is a chronic, heterogeneous disease of the airways, often characterised by structural changes known collectively as airway remodelling. In response to environmental insults, including pathogens, allergens and pollutants, the...