Peter Bradding
Overview
Explore the profile of Peter Bradding including associated specialties, affiliations and a list of published articles.
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154
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5917
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Recent Articles
1.
Maxwell C, Stylianou P, Marshall H, Hall A, Quinn P, Ng L, et al.
Eur J Pharmacol
. 2025 Mar;
997:177461.
PMID: 40049575
Introduction: Novel treatments for idiopathic pulmonary fibrosis (IPF) are needed urgently. A better understanding of the molecular pathways activated by TGFβ1 in human lung tissue may facilitate the development of...
2.
Daud T, Roberts S, Kermani N, Richardson M, Heaney L, Adcock I, et al.
Allergy
. 2025 Jan;
PMID: 39749571
Background: Airway remodelling is a feature of severe asthma with airway epithelial damage observed frequently. We evaluated the role of WNT5a and TGF-β in asthmatic airway biopsies and in sputum...
3.
Rhee H, Henderson L, Bauer R, Wong K, Staton T, Choy D, et al.
Allergy
. 2024 Sep;
79(11):2993-3004.
PMID: 39250147
Background: Tryptase, a mast cell protease, has been identified as a potential therapeutic target in managing patients with refractory asthma. We assessed the efficacy, safety, pharmacokinetics, and pharmacodynamics of MTPS9579A,...
4.
Marchi E, Hinks T, Richardson M, Khalfaoui L, Symon F, Rajasekar P, et al.
Allergy
. 2024 Apr;
79(7):1831-1843.
PMID: 38686450
Background: The effects of inhaled corticosteroids (ICS) on healthy airways are poorly defined. Objectives: To delineate the effects of ICS on gene expression in healthy airways, without confounding caused by...
5.
Djukanovic R, Brinkman P, Kolmert J, Gomez C, Schofield J, Brandsma J, et al.
Am J Respir Crit Care Med
. 2024 Apr;
210(3):288-297.
PMID: 38635834
The anti-IgE monoclonal antibody omalizumab is widely used for severe asthma. This study aimed to identify biomarkers that predict clinical improvement during 1 year of omalizumab treatment. One-year open-label Study...
6.
Aung H, Boddy C, Hampson E, Bell M, Parnell L, Balasundaram K, et al.
J Allergy Clin Immunol Pract
. 2024 Mar;
12(6):1539-1546.e5.
PMID: 38518866
Background: Sixty-five percent of people with severe asthma and a fractional exhaled nitric oxide (Feno) greater than or equal to 45 parts per billion (ppb) are nonadherent to inhaled corticosteroids...
7.
Bradding P, Porsbjerg C, Cote A, Dahlen S, Hallstrand T, Brightling C
J Allergy Clin Immunol
. 2024 Feb;
153(5):1181-1193.
PMID: 38395082
Airway hyperresponsiveness (AHR) is a key clinical feature of asthma. The presence of AHR in people with asthma provides the substrate for bronchoconstriction in response to numerous diverse stimuli, contributing...
8.
Apps L, Chantrell S, Majd S, Eglinton E, Singh S, Murphy A, et al.
J Allergy Clin Immunol Pract
. 2023 Jul;
11(11):3435-3444.e2.
PMID: 37453572
Background: Adults living with severe asthma have lower physical activity levels, particularly high-intensity physical activity, compared with their healthy peers. Physical inactivity is associated with increased morbidity and mortality. Objective:...
9.
Zeng X, Qing J, Li C, Lu J, Yamawaki T, Hsu Y, et al.
J Allergy Clin Immunol
. 2023 Jun;
152(4):876-886.
PMID: 37315813
Background: Patients with type-2 (T2) cytokine-low severe asthma often have persistent symptoms despite suppression of T2 inflammation with corticosteroids. Objectives: We sought to analyze whole blood transcriptome from 738 samples...
10.
Eastwood M, Busby J, Jackson D, Pavord I, Hanratty C, Djukanovic R, et al.
J Allergy Clin Immunol Pract
. 2023 Jan;
11(4):1233-1242.e5.
PMID: 36621603
Background: Approximately 5% to 10% of patients with asthma have severe disease, with a consistent preponderance in females. Current asthma guidelines recommend stepwise treatment to achieve symptom control with no...