Christopher D Scharer
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Explore the profile of Christopher D Scharer including associated specialties, affiliations and a list of published articles.
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89
Citations
2651
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Recent Articles
1.
Wiggins K, Williams M, Hicks S, Padilla-Quirarte H, Akther J, Randall T, et al.
J Immunol
. 2025 Mar;
PMID: 40073167
Antigen-experienced memory B-cells (MBC) are endowed with enhanced functional properties compared to naïve B cells and play an important role in the humoral response. However, the epigenetic enzymes and programs...
2.
Toothacre N, Rodriguez-Acevedo K, Wiggins K, Scharer C, Anguera M
bioRxiv
. 2025 Feb;
PMID: 39975415
X-Chromosome Inactivation (XCI) involves epigenetic pathways to equalize X-linked gene expression between female and male mammals. XCI is dynamic in female B cells, as cytological enrichment of Xist RNA and...
3.
Nielsen H, Yang L, Mueller J, Ritter A, Hiwa R, Proekt I, et al.
Nat Commun
. 2025 Jan;
16(1):784.
PMID: 39824797
The Nr4a nuclear hormone receptors are transcriptionally upregulated in response to antigen recognition by the T cell receptor (TCR) in the thymus and are implicated in clonal deletion, but the...
4.
Elkins C, Ye C, Sivasami P, Mulpur R, Diaz-Saldana P, Peng A, et al.
Sci Immunol
. 2025 Jan;
10(103):eadl4909.
PMID: 39792637
Regulatory T cells (T) accumulate in the visceral adipose tissue (VAT) to maintain systemic metabolic homeostasis but decline during obesity. Here, we explored the metabolic pathways controlling the homeostasis, composition,...
5.
McManus D, Valanparambil R, Medina C, Scharer C, McGuire D, Sobierajska E, et al.
Nature
. 2025 Jan;
PMID: 39778710
This study examines the origin and differentiation of stem-like CD8 T cells that are essential for sustained T cell immunity in chronic viral infections and cancer and also have a...
6.
Faliti C, Van T, Anam F, Cheedarla N, Williams M, Mishra A, et al.
Nat Immunol
. 2024 Dec;
26(1):148.
PMID: 39622950
No abstract available.
7.
Faliti C, Mesina M, Choi J, Belanger S, Marshall M, Tipton C, et al.
Immunity
. 2024 Nov;
57(12):2772-2789.e8.
PMID: 39612915
During antigen-driven responses, B cells can differentiate at extra-follicular (EF) sites or initiate germinal centers (GCs) in processes that involve interactions with T cells. Here, we examined the roles of...
8.
Faliti C, Van T, Anam F, Cheedarla N, Williams M, Mishra A, et al.
Nat Immunol
. 2024 Nov;
26(1):131-145.
PMID: 39533072
Severe acute respiratory syndrome coronavirus 2 mRNA vaccination has reduced effectiveness in certain immunocompromised individuals. However, the cellular mechanisms underlying these defects, as well as the contribution of disease-induced cellular...
9.
Zhong Z, Quinones-Perez M, Dai Z, Juarez V, Bhatia E, Carlson C, et al.
Nat Mater
. 2024 Nov;
24(2):297-311.
PMID: 39506098
Antibodies are produced when naive B cells differentiate into plasma cells within germinal centres (GCs) of lymphoid tissues. Patients with B cell lymphoma on effective immunotherapies exhibit diminished antibody production,...
10.
Weiss S, Huang A, Fung M, Martinez D, Chen A, LaSalle T, et al.
Nat Immunol
. 2024 Sep;
25(10):1871-1883.
PMID: 39289557
PD-1 is a key negative regulator of CD8 T cell activation and is highly expressed by exhausted T cells in cancer and chronic viral infection. Although PD-1 blockade can improve...