Christopher C Harris
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Explore the profile of Christopher C Harris including associated specialties, affiliations and a list of published articles.
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17
Citations
7788
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Recent Articles
1.
Weiss J, Hunter M, Cruz N, Baggiolini A, Tagore M, Ma Y, et al.
Nature
. 2022 Mar;
604(7905):354-361.
PMID: 35355015
Oncogenic alterations to DNA are not transforming in all cellular contexts. This may be due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic position as...
2.
Griffith M, Griffith O, Smith S, Ramu A, Callaway M, Brummett A, et al.
PLoS Comput Biol
. 2015 Jul;
11(7):e1004274.
PMID: 26158448
In this work, we present the Genome Modeling System (GMS), an analysis information management system capable of executing automated genome analysis pipelines at a massive scale. The GMS framework provides...
3.
Field E, Sczyrba A, Lyman A, Harris C, Woyke T, Stepanauskas R, et al.
ISME J
. 2014 Oct;
9(4):857-70.
PMID: 25303714
The Zetaproteobacteria are a candidate class of marine iron-oxidizing bacteria that are typically found in high iron environments such as hydrothermal vent sites. As much remains unknown about these organisms...
4.
Swan B, Chaffin M, Martinez-Garcia M, Morrison H, Field E, Poulton N, et al.
PLoS One
. 2014 Apr;
9(4):e95380.
PMID: 24743558
Marine Group I (MGI) Thaumarchaeota are one of the most abundant and cosmopolitan chemoautotrophs within the global dark ocean. To date, no representatives of this archaeal group retrieved from the...
5.
Ewing A, Ballinger T, Earl D, Harris C, Ding L, Wilson R, et al.
Genome Biol
. 2013 Mar;
14(3):R22.
PMID: 23497673
Background: Retroposed processed gene transcripts are an important source of material for new gene formation on evolutionary timescales. Most prior work on gene retrocopy discovery compared copies in reference genome...
6.
Welch J, Ley T, Link D, Miller C, Larson D, Koboldt D, et al.
Cell
. 2012 Jul;
150(2):264-78.
PMID: 22817890
Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML), normal...
7.
Lee E, Iskow R, Yang L, Gokcumen O, Haseley P, Luquette 3rd L, et al.
Science
. 2012 Jun;
337(6097):967-71.
PMID: 22745252
Transposable elements (TEs) are abundant in the human genome, and some are capable of generating new insertions through RNA intermediates. In cancer, the disruption of cellular mechanisms that normally suppress...
8.
Ellis M, Ding L, Shen D, Luo J, Suman V, Wallis J, et al.
Nature
. 2012 Jun;
486(7403):353-60.
PMID: 22722193
To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two studies of neoadjuvant aromatase inhibitor therapy by...
9.
Polotsky M, Elsayed-Ahmed A, Pichard L, Harris C, Smith P, Schneider H, et al.
J Appl Physiol (1985)
. 2012 Feb;
112(10):1637-43.
PMID: 22345430
Obesity is associated with alterations in upper airway collapsibility during sleep. Obese, leptin-deficient mice demonstrate blunted ventilatory control, leading us to hypothesize that (1) obesity and leptin deficiency would predispose...
10.
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley S, Payne-Turner D, et al.
Nature
. 2012 Jan;
481(7380):157-63.
PMID: 22237106
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases and assessed the frequency of...