Christopher A McPherson
Overview
Explore the profile of Christopher A McPherson including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
1309
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0
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Recent Articles
1.
Kanungo J, Sorkin B, Krzykwa J, Mitchell C, Embry M, Spencer P, et al.
Expert Opin Drug Metab Toxicol
. 2024 Jul;
20(7):629-646.
PMID: 38984683
Areas Covered: This paper outlines the selection of NAMs, including in vitro assays using primary rat cortical neurons, zebrafish embryos, and . These assays aim to assess neurotoxic endpoints such...
2.
McPherson C, Kelly-Rajan K, Lefebvre dHellencourt C, Harry G
Curr Protoc
. 2023 Jan;
3(1):e638.
PMID: 36622815
Microglia function as the tissue-specific resident macrophages of the nervous system, performing immune and non-immune functions. These functions are critical to development and to maintain homeostasis in the nervous system...
3.
Bowen C, Childers G, Perry C, Martin N, McPherson C, Lauten T, et al.
Chemosphere
. 2020 May;
255:126919.
PMID: 32402876
The predominant reliance on bromated flame retardants (BFRs) is diminishing with expanded use of alternative organophosphate flame retardants. However, exposure related issues for susceptible populations, the developing, infirmed, or aged,...
4.
Goulding D, Kraft A, Mouton P, McPherson C, Avdoshina V, Mocchetti I, et al.
Neurotox Res
. 2019 Jul;
36(3):563-582.
PMID: 31286433
Animal models have been used to study cellular processes related to human immunodeficiency virus-1 (HIV-1)-associated neurocognitive disorders (HAND). The HIV-1 transgenic (Tg) rat expresses HIV viral genes except the gag-pol...
5.
McPherson C, Zhang G, Gilliam R, Brar S, Wilson R, Brix A, et al.
Neurotox Res
. 2018 Feb;
34(4):781-798.
PMID: 29404855
At elevated levels, fluoride (F) exposure has been associated with adverse human health effects. In rodents, F exposure has been reported to induce deficits in motor performance and learning and...
6.
Kraft A, McPherson C, Harry G
Neurotox Res
. 2016 Feb;
30(1):53-66.
PMID: 26892644
Complement-associated factors are implicated in pathogen presentation, neurodegeneration, and microglia resolution of tissue injury. To characterize complement activation with microglial clearance of degenerating mossy fiber boutons, hippocampal dentate granule neurons...
7.
Orihuela R, McPherson C, Harry G
Br J Pharmacol
. 2015 Mar;
173(4):649-65.
PMID: 25800044
Microglia are critical nervous system-specific immune cells serving as tissue-resident macrophages influencing brain development, maintenance of the neural environment, response to injury and repair. As influenced by their environment, microglia...
8.
Brunssen S, Moy S, Toews A, McPherson C, Harry G
Brain Behav Immun
. 2012 Sep;
27(1):42-53.
PMID: 22985907
Adverse neurodevelopmental outcomes are linked to perinatal production of inflammatory mediators, including interleukin 6 (IL-6). While a pivotal role for maternal elevation in IL-6 has been established in determining neurobehavioral...
9.
Funk J, Gohlke J, Kraft A, McPherson C, Collins J, Harry G
Brain Behav Immun
. 2011 Mar;
25(6):1063-77.
PMID: 21435392
In the periphery, exercise induces interleukin (IL)-6 to downregulate tumor necrosis factor (TNF), elevate interleukin-1 receptor antagonist (IL-1RA), decreasing inflammation. Exercise also offers neuroprotection and facilitates brain repair. IL-6 production...
10.
McPherson C, Kraft A, Harry G
Neurotox Res
. 2010 Jun;
19(2):341-52.
PMID: 20524106
The induction of neurogenesis in the adult subgranular zone (SGZ) by injury is often accompanied by changes in the extracellular environment that can have significant impacts on neural progenitor cells...