Christopher A Klug
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Explore the profile of Christopher A Klug including associated specialties, affiliations and a list of published articles.
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45
Citations
899
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Recent Articles
11.
DeVore 2nd M, Klug C, Kriz M, Roy L, Wellons M
J Phys Chem A
. 2018 Jul;
122(34):6873-6878.
PMID: 30047731
High-resolution F magic-angle spinning (MAS) NMR spectra were obtained for the uranium-bearing solid uranyl fluoride sesquihydrate (UOF·1.57HO). While there are seven distinct crystallographic fluorine sites, the F NMR spectrum reveals...
12.
Klug C, Miller J
Solid State Nucl Magn Reson
. 2018 May;
92:14-18.
PMID: 29729494
The automated detection of broad NMR spectra via the controlled stepwise motion of the NMR probe along the field axis of the superconducting solenoid is demonstrated for the detection of...
13.
Oh E, Delehanty J, Klug C, Susumu K, Algar W, Goswami R, et al.
Chem Commun (Camb)
. 2018 Jan;
54(16):1956-1959.
PMID: 29319069
Water soluble metallic nanoparticles are being developed for a variety of roles ranging from catalysis to drug delivery and as potential contrast agents. We demonstrate direct synthesis of high-quality water-soluble...
14.
He Q, Scott Swindle C, Wan C, Flynn R, Oster R, Chen D, et al.
Stem Cells
. 2016 Aug;
35(2):473-484.
PMID: 27539014
Long-term self-renewing hematopoietic stem cell (LT-HSC) homeostasis within the bone marrow (BM) of adult mammals is regulated by complex interactions between LT-HSC and a number of niche-associated cell types including...
15.
Schultz M, Holdbrooks A, Chakraborty A, Grizzle W, Landen C, Buchsbaum D, et al.
Cancer Res
. 2016 May;
76(13):3978-88.
PMID: 27216178
The glycosyltransferase ST6Gal-I, which adds α2-6-linked sialic acids to substrate glycoproteins, has been implicated in carcinogenesis; however, the nature of its pathogenic role remains poorly understood. Here we show that...
16.
Gu Y, Jones A, Yang W, Liu S, Dai Q, Liu Y, et al.
Proc Natl Acad Sci U S A
. 2015 Dec;
113(1):E51-60.
PMID: 26699484
Epigenetic mechanisms play important regulatory roles in hematopoiesis and hematopoietic stem cell (HSC) function. Subunits of polycomb repressive complex 1 (PRC1), the major histone H2A ubiquitin ligase, are critical for...
17.
Ludwig M, Kojima K, Bowersock G, Chen D, Jhala N, Buchsbaum D, et al.
Proteomics
. 2015 Nov;
16(3):516-31.
PMID: 26572242
We have applied a serologic proteomic workflow involving three complementary MS approaches to a tissue-specific Kras(G12D) -knockin mouse model of pancreatic cancer that consistently forms precancerous lesions by 4 months...
18.
Kojima K, Bowersock G, Kojima C, Klug C, Grizzle W, Mobley J
Proteomics
. 2012 Sep;
12(22):3393-402.
PMID: 22997103
A number of reports have recently emerged with focus on extraction of proteins from formalin-fixed paraffin-embedded (FFPE) tissues for MS analysis; however, reproducibility and robustness as compared to flash frozen...
19.
Klug C
Blood
. 2012 Mar;
119(13):2976-7.
PMID: 22461472
In this issue of Blood,Matsuura and colleagues provide evidence that loss of GMCSF signaling promotes leukemic progression in association with one of the most frequently observed cytogenetic abnormalities in AML,...
20.
Nick H, Kim H, Chang C, Harris K, Reddy V, Klug C
Blood
. 2011 Sep;
119(6):1522-31.
PMID: 21937700
The t(8;21) RUNX1-ETO translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukemia (AML). In RUNX1-ETO(+) patient samples, differing classes of activating c-KIT receptor tyrosine kinase mutations...