Christoforos Tsantoulas
Overview
Explore the profile of Christoforos Tsantoulas including associated specialties, affiliations and a list of published articles.
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19
Citations
838
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Recent Articles
1.
Tsantoulas C, Ng A, Pinto L, Andreou A, McNaughton P
J Neurosci
. 2023 Jan;
42(40):7513-7529.
PMID: 36658457
Migraine is believed to be initiated by neuronal activity in the CNS, that triggers excitation of nociceptive trigeminal ganglion (TG) nerve fibers innervating the meninges and thus causes a unilateral...
2.
Ciotu C, Tsantoulas C, Meents J, Lampert A, McMahon S, Ludwig A, et al.
Int J Mol Sci
. 2019 Sep;
20(18).
PMID: 31540178
Ion channels contribute fundamental properties to cell membranes. Although highly diverse in conductivity, structure, location, and function, many of them can be regulated by common mechanisms, such as voltage or...
3.
Lainez S, Tsantoulas C, Biel M, McNaughton P
J Physiol
. 2019 Jul;
597(17):4661-4675.
PMID: 31290157
Key Points: HCN ion channels conducting the I current control the frequency of firing in peripheral sensory neurons signalling pain. Previous studies have demonstrated a major role for the HCN2...
4.
Tsantoulas C, Denk F, Signore M, Nassar M, Futai K, McMahon S
Pain
. 2018 Apr;
159(8):1641-1651.
PMID: 29697531
Voltage-gated potassium (Kv) channels are increasingly recognised as key regulators of nociceptive excitability. Kcns1 is one of the first potassium channels to be associated with neuronal hyperexcitability and mechanical sensitivity...
5.
Tsantoulas C, Lainez S, Wong S, Mehta I, Vilar B, McNaughton P
Sci Transl Med
. 2017 Sep;
9(409):eaam6072.
PMID: 28954930
Diabetic patients frequently suffer from continuous pain that is poorly treated by currently available analgesics. We used mouse models of type 1 and type 2 diabetes to investigate a possible...
6.
Tsantoulas C, Mooney E, McNaughton P
Biochem J
. 2016 Sep;
473(18):2717-36.
PMID: 27621481
Nociception - the ability to detect painful stimuli - is an invaluable sense that warns against present or imminent damage. In patients with chronic pain, however, this warning signal persists...
7.
Busserolles J, Tsantoulas C, Eschalier A, Lopez Garcia J
Pain
. 2016 Jan;
157 Suppl 1:S7-S14.
PMID: 26785158
A workshop of the 2015 International Neuropathic Pain Congress was focused on potassium channels to propose emerging ideas on the role of these channels on pain modulation and to determine...
8.
Tsantoulas C
Curr Opin Support Palliat Care
. 2015 Apr;
9(2):147-54.
PMID: 25872119
Purpose Of Review: Poor management of chronic pain remains a significant cause of misery with huge socioeconomic costs. Accumulating research in potassium (K+) channel physiology has uncovered several promising leads...
9.
10.
Young G, Emery E, Mooney E, Tsantoulas C, McNaughton P
Pain
. 2014 May;
155(9):1708-1719.
PMID: 24861581
Previous studies have shown that hyperpolarisation-activated cyclic nucleotide-gated (HCN)-2 ion channels regulate the firing frequency of nociceptive sensory neurons and thus play a central role in both inflammatory and neuropathic...