Peter A McNaughton
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Explore the profile of Peter A McNaughton including associated specialties, affiliations and a list of published articles.
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51
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2348
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Recent Articles
1.
Pinto L, Vilar B, McNaughton P
Brain Behav Immun
. 2024 Dec;
125:268-279.
PMID: 39736364
Angiotensin II is well known to have an important influence on blood pressure, mediated via the angiotensin II type 1 receptor (AT1R), but more recent studies have shown that angiotensin...
2.
Wallace M, Berger J, Hockley A, Sumner C, Akeroyd M, Palmer A, et al.
Front Neurosci
. 2024 Aug;
18:1452450.
PMID: 39170684
Rodent models of tinnitus are commonly used to study its mechanisms and potential treatments. Tinnitus can be identified by changes in the gap-induced prepulse inhibition of the acoustic startle (GPIAS),...
3.
Kimourtzis G, Rangwani N, Jenkins B, Jani S, McNaughton P, Raouf R
Sci Rep
. 2024 Jul;
14(1):17360.
PMID: 39075089
Prostaglandin E2 (PGE2) is a major contributor to inflammatory pain hyperalgesia, however, the extent to which it modulates the activity of nociceptive axons is incompletely understood. We developed and characterized...
4.
Han X, Pinto L, Vilar B, McNaughton P
J Neurosci
. 2023 Dec;
44(6).
PMID: 38124021
Prolonged exposure to opioids causes an enhanced sensitivity to painful stimuli (opioid-induced hyperalgesia, OIH) and a need for increased opioid doses to maintain analgesia (opioid-induced tolerance, OIT), but the mechanisms...
5.
Tsantoulas C, Ng A, Pinto L, Andreou A, McNaughton P
J Neurosci
. 2023 Jan;
42(40):7513-7529.
PMID: 36658457
Migraine is believed to be initiated by neuronal activity in the CNS, that triggers excitation of nociceptive trigeminal ganglion (TG) nerve fibers innervating the meninges and thus causes a unilateral...
6.
Buijs T, Vilar B, Tan C, McNaughton P
EMBO J
. 2022 Dec;
42(3):e111348.
PMID: 36524441
Moderate coolness is sensed by TRPM8 ion channels in peripheral sensory nerves, but the mechanism by which noxious cold is detected remains elusive. Here, we show that somatosensory and sympathetic...
7.
Morad H, Luqman S, Pinto L, Cunningham K, Vilar B, Clayton G, et al.
Sci Rep
. 2022 Jun;
12(1):11078.
PMID: 35773325
Immune cell chemotaxis to the sites of pathogen invasion is critical for fighting infection, but in life-threatening conditions such as sepsis and Covid-19, excess activation of the innate immune system...
8.
Watson M, Almeida T, Ray A, Hanack C, Elston R, Btesh J, et al.
J Mol Biol
. 2022 Jun;
434(16):167682.
PMID: 35697294
Disordered scaffold proteins provide multivalent landing pads that, via a series of embedded Short Linear Motifs (SLiMs), bring together the components of a complex to orchestrate precise spatial and temporal...
9.
Bernard Healey S, Scholtes I, Abrahams M, McNaughton P, Menon D, Lee M
Pain Rep
. 2021 Oct;
6(4):e967.
PMID: 34712888
Introduction: Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels mediate repetitive action potential firing in the heart and nervous system. The HCN2 isoform is expressed in nociceptors, and preclinical studies suggest a...
10.
Swire M, Assinck P, McNaughton P, Lyons D, ffrench-Constant C, Livesey M
J Neurosci
. 2021 Aug;
41(38):7954-7964.
PMID: 34341156
Oligodendrocytes generate myelin sheaths vital for the formation, health, and function of the CNS. Myelin sheath length is a key property that determines axonal conduction velocity and is known to...