Christine Xu
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Explore the profile of Christine Xu including associated specialties, affiliations and a list of published articles.
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66
Citations
473
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Recent Articles
1.
Dellon E, Kosloski M, Shabbir A, Glotfelty L, Xu C, Kamal M
Clin Transl Gastroenterol
. 2025 Jan;
16(1):e00793.
PMID: 39853721
Introduction: We assessed potential mechanisms behind the requirement for more frequent dupilumab dosing in eosinophilic esophagitis (EoE) compared with other approved indications. Methods: Results for the phase 3 LIBERTY EoE...
2.
Evans A, Park H, Woods C, Lam R, Rijsketic D, Xu C, et al.
J Neuroinflammation
. 2024 Dec;
21(1):322.
PMID: 39696597
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse...
3.
Zaph S, Leiser R, Tao M, Kaddi C, Xu C
Handb Exp Pharmacol
. 2024 Dec;
PMID: 39673036
Quantitative Systems Pharmacology (QSP) models offer a promising approach to extrapolate drug efficacy across different patient populations, particularly in rare diseases. Unlike conventional empirical models, QSP models can provide a...
4.
Evans A, Park H, Woods C, Lam R, Rijsketic D, Xu C, et al.
Res Sq
. 2024 Nov;
PMID: 39574895
Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse models...
5.
Xu C, Xin K, Kosloski M, Butler A, Goulaouic H, Nivens M, et al.
Clin Pharmacol Drug Dev
. 2024 Sep;
13(11):1181-1188.
PMID: 39308293
Itepekimab, a monoclonal antibody against interleukin-33, has demonstrated clinical utility in previous studies in patients with asthma and chronic obstructive pulmonary disease. An autoinjector (AI) has been developed for administering...
6.
McCann M, Kosloski M, Xu C, Davis J, Kamal M
Clin Transl Sci
. 2024 Jul;
17(8):e13899.
PMID: 39080841
Allergic disease prevalence has increased globally with the subset of type 2 inflammatory diseases playing a substantial role. Type 2 inflammatory diseases may differ in clinical presentation, but they exhibit...
7.
Beck L, Bissonnette R, Deleuran M, Nakahara T, Galus R, Coleman A, et al.
JAMA Dermatol
. 2024 Jul;
160(8):805-812.
PMID: 38985486
Importance: Moderate to severe atopic dermatitis (AD) is a chronic inflammatory skin disease that often requires continuous long-term systemic management. Long-term safety and efficacy data for treatment options are critically...
8.
Rollison H, Mitra P, Chanteux H, Fang Z, Liang X, Park S, et al.
Drug Metab Dispos
. 2024 May;
52(7):582-596.
PMID: 38697852
The International Consortium for Innovation and Quality in Pharmaceutical Development Transporter Working Group had a rare opportunity to analyze a crosspharma collation of in vitro data and assay methods for...
9.
Wechsler M, Souza-Machado A, Xu C, Mao X, Kapoor U, Khokhar F, et al.
J Allergy Clin Immunol Glob
. 2023 Oct;
1(1):9-15.
PMID: 37780074
Background: The safety and tolerability of live attenuated vaccines in patients administered dupilumab for moderate-to-severe asthma have not been previously evaluated. During the LIBERTY ASTHMA TRAVERSE open-label extension study (ClinicalTrials.gov...
10.
Tariq N, Xu C, Wang J, Kume T, Macgregor Jr R
Biophys Chem
. 2023 Jun;
299:107043.
PMID: 37285661
The solute urea has been used extensively as a denaturant in protein folding studies; double-stranded nucleic acid structures are also destabilized by urea, but comparatively less than proteins. In previous...