Christine L Chaffer
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Explore the profile of Christine L Chaffer including associated specialties, affiliations and a list of published articles.
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30
Citations
7027
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Recent Articles
1.
Sahoo S, Ramu S, Nair M, Pillai M, San Juan B, Milioli H, et al.
iScience
. 2024 Jul;
27(7):110116.
PMID: 38974967
Intra-tumoral phenotypic heterogeneity promotes tumor relapse and therapeutic resistance and remains an unsolved clinical challenge. Decoding the interconnections among different biological axes of plasticity is crucial to understand the molecular...
2.
Phan T, Weilbaecher K, Aft R, Croucher P, Chaffer C
Cancer Discov
. 2024 Apr;
14(4):643-647.
PMID: 38571433
Understandably, conventional therapeutic strategies have focused on controlling primary tumors. We ask whether the cost of such strategies is actually an increased likelihood of metastatic relapse.
3.
Sahoo S, Ramu S, Nair M, Pillai M, San Juan B, Milioli H, et al.
bioRxiv
. 2023 Oct;
PMID: 37873432
Intra-tumoral phenotypic heterogeneity promotes tumor relapse and therapeutic resistance and remains an unsolved clinical challenge. It manifests along multiple phenotypic axes and decoding the interconnections among these different axes is...
4.
Waryah C, Cursons J, Foroutan M, Pflueger C, Wang E, Molania R, et al.
Adv Sci (Weinh)
. 2023 May;
10(22):e2301802.
PMID: 37217832
Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome...
5.
Amodio M, Youlten S, Venkat A, San Juan B, Chaffer C, Krishnaswamy S
Patterns (N Y)
. 2022 Sep;
3(9):100577.
PMID: 36124302
Exciting advances in technologies to measure biological systems are currently at the forefront of research. The ability to gather data along an increasing number of omic dimensions has created a...
6.
Burkhardt D, San Juan B, Lock J, Krishnaswamy S, Chaffer C
Cancer Discov
. 2022 Jun;
12(8):1847-1859.
PMID: 35736000
Abstract: Phenotypic plasticity describes the ability of cancer cells to undergo dynamic, nongenetic cell state changes that amplify cancer heterogeneity to promote metastasis and therapy evasion. Thus, cancer cells occupy...
7.
San Juan B, Garcia-Leon M, Rangel L, Goetz J, Chaffer C
Cancers (Basel)
. 2019 Oct;
11(10).
PMID: 31623163
Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase...
8.
Chaffer C, Goetz J
Dev Cell
. 2018 Dec;
47(6):691-693.
PMID: 30562512
Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44,...
9.
Castano Z, San Juan B, Spiegel A, Pant A, DeCristo M, Laszewski T, et al.
Nat Cell Biol
. 2018 Aug;
20(9):1084-1097.
PMID: 30154549
Lack of insight into mechanisms governing breast cancer metastasis has precluded the development of curative therapies. Metastasis-initiating cancer cells (MICs) are uniquely equipped to establish metastases, causing recurrence and therapeutic...
10.
Li J, Choi P, Chaffer C, Labella K, Hwang J, Giacomelli A, et al.
Elife
. 2018 Jul;
7.
PMID: 30059005
Alternative splicing of mRNA precursors represents a key gene expression regulatory step and permits the generation of distinct protein products with diverse functions. In a genome-scale expression screen for inducers...