Christine Fagotto-Kaufmann
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Explore the profile of Christine Fagotto-Kaufmann including associated specialties, affiliations and a list of published articles.
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12
Citations
361
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Recent Articles
1.
Aslemarz A, Fagotto-Kaufmann M, Ruppel A, Fagotto-Kaufmann C, Balland M, Lasko P, et al.
EMBO J
. 2024 Nov;
44(1):75-106.
PMID: 39572744
EpCAM and its close relative Trop2 are well-known cell surface markers of carcinoma, but their potential role in cancer metastasis remains unclear. They are known, however, to downregulate myosin-dependent contractility,...
2.
Bou Malhab L, Schmidt S, Fagotto-Kaufmann C, Pion E, Gadea G, Roux P, et al.
Cells
. 2024 Oct;
13(19.
PMID: 39404389
Mdmx (Mdm4) is established as an oncogene mainly through repression of the p53 tumour suppressor. On the other hand, anti-oncogenic functions for Mdmx have also been proposed, but the underlying...
3.
Bonnet M, Roche F, Fagotto-Kaufmann C, Gazdagh G, Truong I, Comunale F, et al.
Mol Psychiatry
. 2023 Jan;
28(4):1527-1544.
PMID: 36717740
The RhoGEF TRIO is known to play a major role in neuronal development by controlling actin cytoskeleton remodeling, primarily through the activation of the RAC1 GTPase. Numerous de novo mutations...
4.
Sanchez-Huertas C, Bonhomme M, Falco A, Fagotto-Kaufmann C, van Haren J, Jeanneteau F, et al.
J Cell Biol
. 2020 Jun;
219(9).
PMID: 32497170
Microtubule (MT) plus-end tracking proteins (+TIPs) are central players in the coordination between the MT and actin cytoskeletons in growth cones (GCs) during axon guidance. The +TIP Navigator-1 (NAV1) is...
5.
Barbosa S, Greville-Heygate S, Bonnet M, Godwin A, Fagotto-Kaufmann C, Kajava A, et al.
Am J Hum Genet
. 2020 Feb;
106(3):338-355.
PMID: 32109419
The Rho-guanine nucleotide exchange factor (RhoGEF) TRIO acts as a key regulator of neuronal migration, axonal outgrowth, axon guidance, and synaptogenesis by activating the GTPase RAC1 and modulating actin cytoskeleton...
6.
Pengelly R, Greville-Heygate S, Schmidt S, Seaby E, Jabalameli M, Mehta S, et al.
J Med Genet
. 2016 Jul;
53(11):735-742.
PMID: 27418539
Background: Neurodevelopmental disorders have challenged clinical genetics for decades, with over 700 genes implicated and many whose function remains unknown. The application of whole-exome sequencing is proving pivotal in closing...
7.
Hubmacher D, Bergeron E, Fagotto-Kaufmann C, Sakai L, Reinhardt D
Biomacromolecules
. 2014 Feb;
15(4):1456-68.
PMID: 24559401
Fibrillin proteins constitute the backbone of extra-cellular macromolecular microfibrils. Mutations in fibrillins cause heritable connective tissue disorders, including Marfan syndrome, dominant Weill-Marchesani syndrome, and stiff skin syndrome. Fibronectin provides a...
8.
Sabatier L, Djokic J, Fagotto-Kaufmann C, Chen M, Annis D, Mosher D, et al.
Biochem J
. 2013 Sep;
456(2):283-95.
PMID: 24070235
Fibrillins constitute the backbone of extracellular multifunctional assemblies present in elastic and non-elastic matrices, termed microfibrils. Assembly of fibrillins into microfibrils and their homoeostasis is poorly understood and is often...
9.
Djokic J, Fagotto-Kaufmann C, Bartels R, Nelea V, Reinhardt D
J Biol Chem
. 2013 Jun;
288(31):22821-35.
PMID: 23782690
Extracellular short fibulins, fibulin-3, -4, and -5, are components of the elastic fiber/microfibril system and are implicated in the formation and homeostasis of elastic tissues. In this study, we report...
10.
Kirschner R, Hubmacher D, Iyengar G, Kaur J, Fagotto-Kaufmann C, Bromme D, et al.
J Biol Chem
. 2011 Jul;
286(37):32810-23.
PMID: 21784848
Mutations in fibrillin-1 give rise to Marfan syndrome (MFS) characterized by vascular, skeletal, and ocular abnormalities. Fibrillins form the backbone of extracellular matrix microfibrils in tissues including blood vessels, bone,...