Christine E Beattie
Overview
Explore the profile of Christine E Beattie including associated specialties, affiliations and a list of published articles.
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47
Citations
2387
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Recent Articles
1.
Xu J, Wu P, Lai T, Sharma P, Canella A, Welker A, et al.
Clin Cancer Res
. 2022 Feb;
28(9):1979-1990.
PMID: 35140124
Purpose: Proficient DNA repair by homologous recombination (HR) facilitates resistance to chemoradiation in glioma stem cells (GSC). We evaluated whether compromising HR by targeting HSP90, a molecular chaperone required for...
2.
Cam M, Charan M, Welker A, Dravid P, Studebaker A, Leonard J, et al.
Neuro Oncol
. 2019 Nov;
22(3):345-356.
PMID: 31763674
Background: Glioblastoma (GBM) remains one of the least successfully treated cancers. It is essential to understand the basic biology of this lethal disease and investigate novel pharmacological targets to treat...
3.
Beattie C, Kolb S
Brain Res
. 2018 Feb;
1693(Pt A):92-97.
PMID: 29462610
Spinal muscular atrophy is caused by deletions or mutations in the SMN1 gene that result in reduced expression of the SMN protein. The SMN protein is an essential molecular chaperone...
4.
Banasavadi-Siddegowda Y, Welker A, An M, Yang X, Zhou W, Shi G, et al.
Neuro Oncol
. 2017 Nov;
20(6):753-763.
PMID: 29106602
Background: In spite of standard multimodal therapy consisting of surgical resection followed by radiation and concurrent chemotherapy, prognosis for glioblastoma (GBM) patients remains poor. The identification of both differentiated and...
5.
Hao le T, Duy P, An M, Talbot J, Iyer C, Wolman M, et al.
J Neurosci
. 2017 Oct;
37(48):11559-11571.
PMID: 29061699
Motoneurons establish a critical link between the CNS and muscles. If motoneurons do not develop correctly, they cannot form the required connections, resulting in movement defects or paralysis. Compromised development...
6.
Canella A, Welker A, Yoo J, Xu J, Abas F, Kesanakurti D, et al.
Clin Cancer Res
. 2017 Jul;
23(20):6215-6226.
PMID: 28679777
HSP90, a highly conserved molecular chaperone that regulates the function of several oncogenic client proteins, is altered in glioblastoma. However, HSP90 inhibitors currently in clinical trials are short-acting, have unacceptable...
7.
Welker A, Jaros B, An M, Beattie C
Neuroscience
. 2017 May;
356:35-43.
PMID: 28526577
Glioblastoma (GBM) is a highly aggressive brain cancer with limited treatments and poor patient survival. GBM tumors are heterogeneous containing a complex mixture of dividing cells, differentiated cells, and cancer...
8.
Duy P, Berberoglu M, Beattie C, Hall C
Neuroscience
. 2017 Feb;
349:118-127.
PMID: 28238851
A seizure is a sustained increase in brain electrical activity that can result in loss of consciousness and injury. Understanding how the brain responds to seizures is important for development...
9.
Ferraiuolo L, Meyer K, Sherwood T, Vick J, Likhite S, Frakes A, et al.
Proc Natl Acad Sci U S A
. 2016 Oct;
113(42):E6496-E6505.
PMID: 27688759
Oligodendrocytes have recently been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). Here we show that, in vitro, mutant superoxide dismutase 1 (SOD1) mouse oligodendrocytes induce WT motor neuron...
10.
Welker A, Jaros B, Puduvalli V, Imitola J, Kaur B, Beattie C
Dis Model Mech
. 2016 Sep;
9(9):1063-5.
PMID: 27604693
No abstract available.