Christine C Hinkle
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Explore the profile of Christine C Hinkle including associated specialties, affiliations and a list of published articles.
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15
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996
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Recent Articles
1.
Zhang H, Xue C, Wang Y, Shi J, Zhang X, Li W, et al.
J Am Heart Assoc
. 2017 Nov;
6(11).
PMID: 29133519
Background: Sustained and dysfunctional macrophage activation promotes inflammatory cardiometabolic disorders, but the role of long intergenic noncoding RNA (lincRNA) in human macrophage activation and cardiometabolic disorders is poorly defined. Through...
2.
Zhang H, Hinkle C, ONeill S, Shi J, Caughey J, Lynch E, et al.
Obesity (Silver Spring)
. 2017 Jun;
25(8):1410-1420.
PMID: 28650582
Objective: The purpose of the study was to explore the impact of dual targeting of C-C motif chemokine receptor-2 (CCR2) and fractalkine receptor (CX3CR1) on the metabolic and inflammatory consequences...
3.
Xue C, Zhang X, Zhang H, Ferguson J, Wang Y, Hinkle C, et al.
Physiol Genomics
. 2017 Apr;
49(6):287-305.
PMID: 28389524
Long intergenic noncoding RNAs (lincRNAs) have emerged as key regulators of cellular functions and physiology. Yet functional lincRNAs often have low, context-specific and tissue-specific expression. We hypothesized that many human...
4.
Zhang H, Xue C, Shah R, Bermingham K, Hinkle C, Li W, et al.
Circ Res
. 2015 Apr;
117(1):17-28.
PMID: 25904599
Rationale: An efficient and reproducible source of genotype-specific human macrophages is essential for study of human macrophage biology and related diseases. Objective: To perform integrated functional and transcriptome analyses of...
5.
Shah R, Hinkle C, Haris L, Shah R, Mehta N, Putt M, et al.
J Clin Endocrinol Metab
. 2012 Aug;
97(11):E2152-9.
PMID: 22893715
Context: Adipose inflammation is a crucial link between obesity and its metabolic complications. Human experimental endotoxemia is a controlled model for the study of inflammatory cardiometabolic responses in vivo. Objective:...
6.
Mehta N, Heffron S, Patel P, Ferguson J, Shah R, Hinkle C, et al.
J Transl Med
. 2012 Jun;
10:124.
PMID: 22709547
Background: Chronic inflammation may contribute to insulin resistance (IR), metabolic syndrome and atherosclerosis although evidence of causality is lacking in humans. We hypothesized that very low-dose experimental endotoxemia would induce...
7.
de la Llera Moya M, McGillicuddy F, Hinkle C, Byrne M, Joshi M, Nguyen V, et al.
Atherosclerosis
. 2012 Mar;
222(2):390-4.
PMID: 22456230
Objectives: Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans. Methods And Results: We employed low-dose human endotoxemia to...
8.
Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis
Ferguson J, Hinkle C, Mehta N, Bagheri R, DerOhannessian S, Shah R, et al.
J Am Coll Cardiol
. 2012 Feb;
59(8):764-72.
PMID: 22340269
Objectives: This study sought to examine the role of lipoprotein-associated phospholipase A₂ (Lp-PLA₂/PLA2G7) in human inflammation and coronary atherosclerosis. Background: Lp-PLA₂ has emerged as a potential therapeutic target in coronary...
9.
Shah R, Hinkle C, Ferguson J, Mehta N, Li M, Qu L, et al.
Diabetes
. 2011 Apr;
60(5):1512-8.
PMID: 21525510
Objective: Leukocyte infiltration of adipose is a critical determinant of obesity-related metabolic diseases. Fractalkine (CX3CL1) and its receptor (CX3CR1) comprise a chemokine system involved in leukocyte recruitment and adhesion in...
10.
Zhang Y, McGillicuddy F, Hinkle C, ONeill S, Glick J, Rothblat G, et al.
Circulation
. 2010 Mar;
121(11):1347-55.
PMID: 20212278
Background: Adipose harbors a large depot of free cholesterol. However, a role for adipose in cholesterol lipidation of high-density lipoprotein (HDL) in vivo is not established. We present the first...