Christian Wohn
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Explore the profile of Christian Wohn including associated specialties, affiliations and a list of published articles.
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9
Citations
458
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Recent Articles
1.
Wohn C, Le Guen V, Voluzan O, Fiore F, Henri S, Malissen B
Sci Immunol
. 2020 Mar;
5(45).
PMID: 32169954
Conventional dendritic cells expressing the XCR1 chemokine receptor (cDC1s) excel at cross-presentation. Here, we developed and used a mouse model in which a Cre recombinase is expressed under the control...
2.
Janela B, Patel A, Lau M, Goh C, Msallam R, Kong W, et al.
Immunity
. 2019 Mar;
50(4):1069-1083.e8.
PMID: 30926233
Skin conventional dendritic cells (cDCs) exist as two distinct subsets, cDC1s and cDC2s, which maintain the balance of immunity to pathogens and tolerance to self and microbiota. Here, we examined...
3.
Mattiuz R, Wohn C, Ghilas S, Ambrosini M, Alexandre Y, Sanchez C, et al.
Front Immunol
. 2018 Dec;
9:2805.
PMID: 30564233
Type 1 conventional DCs (cDC1) excel in the cross-priming of CD8 T cells, which is crucial for orchestrating efficient immune responses against viruses or tumors. However, our understanding of their...
4.
Schuler R, Brand A, Klebow S, Wild J, Veras F, Ullmann E, et al.
J Invest Dermatol
. 2018 Oct;
139(3):638-647.
PMID: 30367871
Besides skin inflammation, patients with severe psoriasis suffer from an increased risk of cardiovascular mortality. IL-17A plays a central role in the development of psoriasis and might connect skin and...
5.
Terhorst D, Chelbi R, Wohn C, Malosse C, Tamoutounour S, Jorquera A, et al.
J Immunol
. 2015 Oct;
195(10):4953-61.
PMID: 26466959
Psoriasis is a chronic inflammatory skin disease of unknown etiology. Previous studies showed that short-term, 5-7 d-long application of imiquimod (IMQ), a TLR7 agonist, to the skin of mice triggers...
6.
Schaft N, Wellner V, Wohn C, Schuler G, Dorrie J
Cancer Immunol Immunother
. 2013 Oct;
62(12):1769-80.
PMID: 24114143
RNA transfection is a standard method to load dendritic cells (DC) with antigen for therapeutic cancer vaccination. While electroporation yields high transfection efficiency and satisfying expression levels, lipofection results in...
7.
Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice
Wohn C, Ober-Blobaum J, Haak S, Pantelyushin S, Cheong C, Zahner S, et al.
Proc Natl Acad Sci U S A
. 2013 Jun;
110(26):10723-8.
PMID: 23754427
Psoriasis is an autoinflammatory skin disease of unknown etiology. Topical application of Aldara cream containing the Toll-like receptor (TLR)7 agonist Imiquimod (IMQ) onto patients induces flares of psoriasis. Likewise, in...
8.
Swindell W, Johnston A, Carbajal S, Han G, Wohn C, Lu J, et al.
PLoS One
. 2011 Apr;
6(4):e18266.
PMID: 21483750
Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models...
9.
Johnston A, Xing X, Guzman A, Riblett M, Loyd C, Ward N, et al.
J Immunol
. 2011 Jan;
186(4):2613-22.
PMID: 21242515
IL-1F6, IL-1F8, and IL-1F9 and the IL-1R6(RP2) receptor antagonist IL-1F5 constitute a novel IL-1 signaling system that is poorly characterized in skin. To further characterize these cytokines in healthy and...