Christian U Stirnimann
Overview
Explore the profile of Christian U Stirnimann including associated specialties, affiliations and a list of published articles.
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16
Citations
1284
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Recent Articles
1.
Hirt C, Booij T, Grob L, Simmler P, Toussaint N, Keller D, et al.
Cell Genom
. 2022 Feb;
2(2):100095.
PMID: 35187519
Pancreatic cancer (PDAC) is a highly aggressive malignancy for which the identification of novel therapies is urgently needed. Here, we establish a human PDAC organoid biobank from 31 genetically distinct...
2.
Karkampouna S, La Manna F, Benjak A, Kiener M, De Menna M, Zoni E, et al.
Nat Commun
. 2021 Feb;
12(1):1117.
PMID: 33602919
Therapy resistance and metastatic processes in prostate cancer (PCa) remain undefined, due to lack of experimental models that mimic different disease stages. We describe an androgen-dependent PCa patient-derived xenograft (PDX)...
3.
Gkountela S, Castro-Giner F, Szczerba B, Vetter M, Landin J, Scherrer R, et al.
Cell
. 2019 Jan;
176(1-2):98-112.e14.
PMID: 30633912
The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain largely unknown. Here, we...
4.
Luna-Zurita L, Stirnimann C, Glatt S, Kaynak B, Thomas S, Baudin F, et al.
Cell
. 2016 Feb;
164(5):999-1014.
PMID: 26875865
Transcription factors (TFs) are thought to function with partners to achieve specificity and precise quantitative outputs. In the developing heart, heterotypic TF interactions, such as between the T-box TF TBX5...
5.
Weber S, Stirnimann C, Wieser M, Frey D, Meier R, Engelhardt S, et al.
J Biol Chem
. 2014 Oct;
289(49):34175-88.
PMID: 25339170
The causative agent of Legionnaires' pneumonia, Legionella pneumophila, colonizes diverse environmental niches, including biofilms, plant material, and protozoa. In these habitats, myo-inositol hexakisphosphate (phytate) is prevalent and used as a...
6.
Benoit R, Frey D, Hilbert M, Kevenaar J, Wieser M, Stirnimann C, et al.
Nature
. 2013 Nov;
505(7481):108-11.
PMID: 24240280
Botulinum neurotoxin A (BoNT/A) belongs to the most dangerous class of bioweapons. Despite this, BoNT/A is used to treat a wide range of common medical conditions such as migraines and...
7.
Bjelic S, Wieser M, Frey D, Stirnimann C, Chance M, Jaussi R, et al.
PLoS One
. 2013 May;
8(5):e63370.
PMID: 23691037
Coiled coils are well suited to drive subunit oligomerization and are widely used in applications ranging from basic research to medicine. The optimization of these applications requires a detailed understanding...
8.
Nowak A, Alfieri C, Stirnimann C, Rybin V, Baudin F, Ly-Hartig N, et al.
J Biol Chem
. 2011 May;
286(26):23388-96.
PMID: 21550984
Drosophila Nurf55 is a component of different chromatin-modifying complexes, including the PRC2 (Polycomb repressive complex 2). Based on the 1.75-Å crystal structure of Nurf55 bound to histone H4 helix 1,...
9.
Stirnimann C, Petsalaki E, Russell R, Muller C
Trends Biochem Sci
. 2010 May;
35(10):565-74.
PMID: 20451393
Recent findings indicate that WD40 domains play central roles in biological processes by acting as hubs in cellular networks; however, they have been studied less intensely than other common domains,...
10.
Stirnimann C, Ptchelkine D, Grimm C, Muller C
J Mol Biol
. 2010 May;
400(1):71-81.
PMID: 20450920
TBX5, a member of the T-box transcription factor family, plays an important role in heart and limb development. More than 60 single point or deletion mutations of human TBX5 are...