Christian Sinzger
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Explore the profile of Christian Sinzger including associated specialties, affiliations and a list of published articles.
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71
Citations
2398
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Recent Articles
11.
Frascaroli G, Sinzger C
Methods Mol Biol
. 2021 Feb;
2244:19-38.
PMID: 33555580
Human cytomegalovirus is routinely isolated by inoculating fibroblast cultures with clinical specimens suspected of harboring HCMV and then monitoring the cultures for cytopathic effects characteristic of this virus. Initially, such...
12.
Reuter N, Kropff B, Schneiderbanger J, Alt M, Krawczyk A, Sinzger C, et al.
J Virol
. 2020 Jul;
94(18).
PMID: 32641474
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that can cause severe clinical disease in allograft recipients and infants infected Virus-neutralizing antibodies defined have been proposed to confer protection against HCMV...
13.
Gabor F, Jahn G, Sedmak D, Sinzger C
Front Cell Infect Microbiol
. 2020 Jun;
10:283.
PMID: 32596168
Based on cell culture data, MHC class I downregulation by HCMV on infected cells has been suggested as a means of immune evasion by this virus. In order to address...
14.
Basilio-Queiros D, Venturini L, Laib Sampaio K, Sinzger C, Weissinger E
Hum Gene Ther Methods
. 2019 Jul;
30(4):122-126.
PMID: 31280610
The study of human cytomegalovirus (HCMV) has for long been challenging due to the inability of clinical strains to efficiently proliferate until adaptive mutations occur. These mutations lead to strains...
15.
Lehmann C, Falk J, Buscher N, Penner I, Zimmermann C, Gogesch P, et al.
J Virol
. 2019 Jun;
93(17).
PMID: 31189713
The development of a vaccine against human cytomegalovirus infection (HCMV) is a high-priority medical goal. The viral pentameric protein complex consisting of glycoprotein H (gH)/gL/UL128-131A (PC) is considered to be...
16.
Stegmann C, Rothemund F, Laib Sampaio K, Adler B, Sinzger C
J Virol
. 2019 Mar;
93(11).
PMID: 30894468
The human cytomegalovirus (HCMV) glycoprotein complex gH/gL/gO is required for the infection of cells by cell-free virions. It was recently shown that entry into fibroblasts depends on the interaction of...
17.
Theobald S, Khailaie S, Meyer-Hermann M, Volk V, Olbrich H, Danisch S, et al.
Front Immunol
. 2018 Dec;
9:2734.
PMID: 30524448
Human cytomegalovirus (HCMV) latency is typically harmless but reactivation can be largely detrimental to immune compromised hosts. We modeled latency and reactivation using a traceable HCMV laboratory strain expressing the...
18.
Abdellatif M, Sinzger C, Walther P
J Struct Biol
. 2018 Oct;
204(3):406-419.
PMID: 30352275
Human cytomegalovirus (HCMV) entry into susceptible cells is a fast intricate process that is not fully understood. Although, previous studies explored different aspects of this process by means of biochemical...
19.
Fast L, Mikulicic S, Fritzen A, Schwickert J, Boukhallouk F, Hochdorfer D, et al.
Int J Mol Sci
. 2018 Oct;
19(10).
PMID: 30279342
Tetraspanins are suggested to regulate the composition of cell membrane components and control intracellular transport, which leaves them vulnerable to utilization by pathogens such as human papillomaviruses (HPV) and cytomegaloviruses...
20.
Falk J, Winkelmann M, Laib Sampaio K, Paal C, Schrezenmeier H, Alt M, et al.
Viruses
. 2018 Sep;
10(9).
PMID: 30223489
Immunoglobulins are only moderately effective for the treatment of human cytomegalovirus (HCMV) infections, possibly due to ineffectiveness against cell-associated virus spread. To overcome this limitation, we aimed to identify individuals...