Christian Sinzger
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Explore the profile of Christian Sinzger including associated specialties, affiliations and a list of published articles.
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71
Citations
2398
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Recent Articles
21.
Alt M, Falk J, Eis-Hubinger A, Kropff B, Sinzger C, Krawczyk A
J Immunol Methods
. 2018 Jul;
462:13-22.
PMID: 30056033
Infections with the herpes simplex virus (HSV) and the human cytomegalovirus (HCMV) can lead to life-threatening diseases, particularly in immunosuppressed patients. Furthermore, HSV infections at birth (herpes neonatorum) can result...
22.
Falk J, Winkelmann M, Stohr D, Alt M, Schrezenmeier H, Krawczyk A, et al.
J Infect Dis
. 2018 Apr;
218(6):876-885.
PMID: 29684155
To improve the potency of anti-human cytomegalovirus (HCMV) immunoglobulin preparations, we intended to find elite neutralizers among 9000 HCMV-seropositive blood donors. We identified the top 2.6% neutralizers by use of...
23.
Laib Sampaio K, Weyell A, Subramanian N, Wu Z, Sinzger C
Biotechniques
. 2017 Nov;
63(5):205-214.
PMID: 29185920
For immunological research on the human cytomegalovirus (HCMV), a virus that combines the broad cell tropism of clinical isolates, efficient replication in cell culture, the complete set of MHC-I modulator...
24.
Stegmann C, Hochdorfer D, Lieber D, Subramanian N, Stohr D, Laib Sampaio K, et al.
PLoS Pathog
. 2017 Apr;
13(4):e1006273.
PMID: 28403220
Human cytomegalovirus (HCMV) is a widely distributed herpesvirus that causes significant morbidity in immunocompromised hosts. Inhibitors of viral DNA replication are available, but adverse effects limit their use. Alternative antiviral...
25.
Maier A, Jung R, Villinger C, Schubert A, Walther P, Sinzger C, et al.
PLoS One
. 2017 Jan;
12(1):e0169580.
PMID: 28060895
Widely used methods for quantification of human cytomegalovirus (HCMV) infection in cell culture such as immunoblotting or plaque reduction assays are generally restricted to low throughput and require time-consuming evaluation....
26.
Falk J, Winkelmann M, Schrezenmeier H, Stohr D, Sinzger C, Lotfi R
Transfusion
. 2016 Nov;
57(2):412-422.
PMID: 27861998
Background: Hyperimmunoglobulins are frequently applied for prophylaxis and treatment of human cytomegalovirus (HCMV) infections but were only marginally effective in meta-analyses of clinical studies. This might be partially due to...
27.
Stegmann C, Abdellatif M, Laib Sampaio K, Walther P, Sinzger C
J Virol
. 2016 Nov;
91(1).
PMID: 27795411
Importance: Like all herpesviruses, the widespread human pathogen HCMV depends on glycoproteins gB, gH, and gL for entry into target cells. Additionally, gH and gL have to bind gO in...
28.
Falk J, Laib Sampaio K, Stegmann C, Lieber D, Kropff B, Mach M, et al.
J Virol Methods
. 2016 Jun;
235:182-189.
PMID: 27326666
For many questions in human cytomegalovirus (HCMV) research, assays are desired that allow robust and fast quantification of infection efficiencies under high-throughput conditions. The secreted Gaussia luciferase has been demonstrated...
29.
Hochdorfer D, Florin L, Sinzger C, Lieber D
J Virol
. 2016 May;
90(14):6430-42.
PMID: 27147745
Unlabelled: Human cytomegalovirus (HCMV), a betaherpesvirus, can cause life-threatening disease in immunocompromised individuals. Viral envelope glycoproteins that mediate binding to and penetration into target cells have been identified previously. In...
30.
Laib Sampaio K, Stegmann C, Brizic I, Adler B, Stanton R, Sinzger C
J Gen Virol
. 2016 Apr;
97(8):1917-1927.
PMID: 27050420
The glycoproteins gH and gL of human cytomegalovirus (HCMV) form a complex either with pUL74 (trimeric complex) or with proteins of the UL128 locus (pentameric complex). While the pentameric complex...