Christian Siebold
Overview
Explore the profile of Christian Siebold including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
89
Citations
4076
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Ansell T, Corey R, Viti L, Kinnebrew M, Rohatgi R, Siebold C, et al.
bioRxiv
. 2023 Feb;
PMID: 36824746
Patched1 (PTCH1) is the principal tumour suppressor protein of the mammalian Hedgehog (HH) signalling pathway, implicated in embryogenesis and tissue homeostasis. PTCH1 inhibits the Class F G protein-coupled receptor Smoothened...
12.
Kinnebrew M, Woolley R, Ansell T, Byrne E, Frigui S, Luchetti G, et al.
Sci Adv
. 2022 Jun;
8(22):eabm5563.
PMID: 35658032
Smoothened (SMO) transduces the Hedgehog (Hh) signal across the plasma membrane in response to accessible cholesterol. Cholesterol binds SMO at two sites: one in the extracellular cysteine-rich domain (CRD) and...
13.
Coupland C, Andrei S, Ansell T, Carrique L, Kumar P, Sefer L, et al.
Mol Cell
. 2021 Dec;
81(24):5025-5038.e10.
PMID: 34890564
The Sonic Hedgehog (SHH) morphogen pathway is fundamental for embryonic development and stem cell maintenance and is implicated in various cancers. A key step in signaling is transfer of a...
14.
Griffiths S, Schwab R, El Omari K, Bishop B, Iverson E, Malinauskas T, et al.
Nat Commun
. 2021 Dec;
12(1):7171.
PMID: 34887403
Hedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP),...
15.
Kinnebrew M, Luchetti G, Sircar R, Frigui S, Viti L, Naito T, et al.
Elife
. 2021 Oct;
10.
PMID: 34698632
A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the...
16.
Ansell T, Curran L, Horrell M, Pipatpolkai T, Letham S, Song W, et al.
J Chem Theory Comput
. 2021 Sep;
17(10):6548-6558.
PMID: 34523933
Specific interactions of lipids with membrane proteins contribute to protein stability and function. Multiple lipid interactions surrounding a membrane protein are often identified in molecular dynamics (MD) simulations and are,...
17.
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei S, Pogranyi B, Mondal M, et al.
Angew Chem Int Ed Engl
. 2021 Mar;
60(24):13542-13547.
PMID: 33768725
The mammalian membrane-bound O-acyltransferase (MBOAT) superfamily is involved in biological processes including growth, development and appetite sensing. MBOATs are attractive drug targets in cancer and obesity; however, information on the...
18.
Robinson R, Griffiths S, van de Haar L, Malinauskas T, van Battum E, Zelina P, et al.
Cell
. 2021 Mar;
184(8):2103-2120.e31.
PMID: 33740419
During cell migration or differentiation, cell surface receptors are simultaneously exposed to different ligands. However, it is often unclear how these extracellular signals are integrated. Neogenin (NEO1) acts as an...
19.
Radhakrishnan A, Rohatgi R, Siebold C
Nat Chem Biol
. 2020 Nov;
16(12):1303-1313.
PMID: 33199907
The Hedgehog (Hh) signaling pathway coordinates cell-cell communication in development and regeneration. Defects in this pathway underlie diseases ranging from birth defects to cancer. Hh signals are transmitted across the...
20.
McGough I, Vecchia L, Bishop B, Malinauskas T, Beckett K, Joshi D, et al.
Nature
. 2020 Jul;
585(7823):85-90.
PMID: 32699409
A relatively small number of proteins have been suggested to act as morphogens-signalling molecules that spread within tissues to organize tissue repair and the specification of cell fate during development....