David I Stuart
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Explore the profile of David I Stuart including associated specialties, affiliations and a list of published articles.
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299
Citations
16865
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Recent Articles
1.
TomoCPT: a generalizable model for 3D particle detection and localization in cryo-electron tomograms
Shah P, Sanchez-Garcia R, Stuart D
Acta Crystallogr D Struct Biol
. 2025 Feb;
81(Pt 2):63-76.
PMID: 39902808
Cryo-electron tomography is a rapidly developing field for studying macromolecular complexes in their native environments and has the potential to revolutionize our understanding of protein function. However, fast and accurate...
2.
Sherry L, Bahar M, Porta C, Fox H, Grehan K, Nasta V, et al.
Nat Commun
. 2025 Jan;
16(1):831.
PMID: 39827284
Polioviruses have caused crippling disease in humans for centuries, prior to the successful development of vaccines in the mid-1900's, which dramatically reduced disease prevalence. Continued use of these vaccines, however,...
3.
Stuart D, Oksanen H, Abrescia N
Subcell Biochem
. 2024 Dec;
105:247-297.
PMID: 39738949
A virus particle must work as a strongroom to protect its genome, but at the same time it must undergo dramatic conformational changes to infect the cell in order to...
4.
Clarke J, Duyvesteyn H, Perez-Martin E, Latisenko U, Porta C, Humphreys K, et al.
J Gen Virol
. 2024 Oct;
105(10).
PMID: 39422666
Foot-and-mouth disease vaccination using inactivated virus is suboptimal, as the icosahedral viral capsids often disassemble into antigenically distinct pentameric units during long-term storage, or exposure to elevated temperature or lowered...
5.
Asor R, Olerinyova A, Burnap S, Kushwah M, Soltermann F, Rudden L, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(40):e2403260121.
PMID: 39298475
Cellular processes are controlled by the thermodynamics of the underlying biomolecular interactions. Frequently, structural investigations use one monomeric binding partner, while ensemble measurements of binding affinities generally yield one affinity...
6.
Duyvesteyn H, Dijokaite-Guraliuc A, Liu C, Supasa P, Kronsteiner B, Jeffery K, et al.
Structure
. 2024 Aug;
32(10):1594-1602.e6.
PMID: 39173622
BA.2.87.1 represents a major shift in the BA.2 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is unusual in having two lengthy deletions of polypeptide in the spike...
7.
Zhang H, El Omari K, Sutton G, Stuart D
J Gen Virol
. 2024 Aug;
105(8).
PMID: 39163113
The unenveloped Bluetongue virus capsid comprises several structural layers, the inner two comprising a core, which assembles before addition of the outer proteins, VP2 and VP5. Two symmetric trimers of...
8.
Thanh T, Tu N, Nguyet L, Thuy C, Thuan N, Ny N, et al.
Int J Infect Dis
. 2024 Aug;
147:107173.
PMID: 39094762
Objectives: We studied the immunogenicity after primary and booster vaccinations of the Abdala COVID-19 vaccine, a receptor-binding domain protein subunit vaccine, in Vietnamese people by determining the level of neutralization...
9.
Nhu L, Chambers M, Chantratita N, Cheah P, Day N, Dejnirattisai W, et al.
Wellcome Open Res
. 2024 Jul;
9:181.
PMID: 39022321
A strong and effective COVID-19 and future pandemic responses rely on global efforts to carry out surveillance of infections and emerging SARS-CoV-2 variants and to act accordingly in real time....
10.
Pouwels K, Eyre D, House T, Aspey B, Matthews P, Stoesser N, et al.
Nat Commun
. 2024 Jun;
15(1):5340.
PMID: 38914564
Population-representative estimates of SARS-CoV-2 infection prevalence and antibody levels in specific geographic areas at different time points are needed to optimise policy responses. However, even population-wide surveys are potentially impacted...