Christian Shema Mugisha
Overview
Explore the profile of Christian Shema Mugisha including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
221
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0
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Recent Articles
1.
Chan R, Mugisha C, Chuenchob V, Moquin S, Manjunatha U, Jarrousse N, et al.
SLAS Discov
. 2024 Nov;
29(8):100189.
PMID: 39499968
Over the past 25 years, the global community has faced challenges posed by three distinct outbreaks of coronaviruses including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus...
2.
Mugisha C, Dinh T, Kumar A, Tenneti K, Eschbach J, Davis K, et al.
mBio
. 2022 Aug;
13(5):e0043122.
PMID: 35975921
HIV-1 integrase (IN) has a noncatalytic function in virion maturation through its binding to the viral RNA genome (gRNA). Class II IN substitutions inhibit IN-gRNA binding and result in the...
3.
Zafferani M, Haddad C, Luo L, Davila-Calderon J, Chiu L, Mugisha C, et al.
Sci Adv
. 2021 Nov;
7(48):eabl6096.
PMID: 34826236
The SARS-CoV-2 pandemic, and the likelihood of future coronavirus pandemics, emphasized the urgent need for development of novel antivirals. Small-molecule chemical probes offer both to reveal aspects of virus replication...
4.
Puray-Chavez M, LaPak K, Schrank T, Elliott J, Bhatt D, Agajanian M, et al.
Cell Rep
. 2021 Jul;
36(2):109364.
PMID: 34214467
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern transmissibility, responsiveness to vaccination, and disease severity. In a screen for new models of SARS-CoV-2 infection, we identify human...
5.
Puray-Chavez M, LaPak K, Schrank T, Elliott J, Bhatt D, Agajanian M, et al.
bioRxiv
. 2021 Mar;
PMID: 33688646
Established models for SARS-CoV-2 infection are limited and include cell lines of non-human origin and those engineered to overexpress ACE2, the cognate host cell receptor. We identified human H522 lung...
6.
Wang Q, Gao H, Clark K, Mugisha C, Davis K, Tang J, et al.
Science
. 2021 Feb;
371(6535).
PMID: 33542150
HIV-1 has high mutation rates and exists as mutant swarms within the host. Rapid evolution of HIV-1 allows the virus to outpace the host immune system, leading to viral persistence....
7.
Mugisha C, Vuong H, Puray-Chavez M, Bailey A, Fox J, Chen R, et al.
mSphere
. 2020 Sep;
5(5).
PMID: 32878932
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions within just a few months, causing severe respiratory disease and mortality. Assays to monitor SARS-CoV-2 growth depend on time-consuming and...
8.
Mugisha C, Vuong H, Puray-Chavez M, Kutluay S
bioRxiv
. 2020 Jul;
PMID: 32607508
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of the ongoing COVID-19 pandemic, has infected millions within just a few months and is continuing to spread around the...
9.
Mugisha C, Tenneti K, Kutluay S
Methods
. 2019 Nov;
183:84-92.
PMID: 31765715
Viral and cellular RNA-binding proteins regulate numerous key steps in the replication of diverse virus genera. Viruses efficiently co-opt the host cell machinery for purposes such as transcription, splicing and...