Christian Leischner
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Explore the profile of Christian Leischner including associated specialties, affiliations and a list of published articles.
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22
Citations
367
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Recent Articles
1.
Schmieder H, Leischner C, Piotrowsky A, Marongiu L, Venturelli S, Burkard M
Immun Ageing
. 2025 Feb;
22(1):8.
PMID: 39962579
The importance of vitamin D for a well-functioning immune system is becoming increasingly evident. Nevertheless, the other fat-soluble vitamins A, E and K also seem to play a central role...
2.
Piotrowsky A, Burkard M, Hammerschmidt K, Ruple H, Nonnenmacher P, Schumacher M, et al.
Antioxidants (Basel)
. 2024 Sep;
13(9).
PMID: 39334754
Several studies have demonstrated, both in vitro and in animal models, the anti-tumor efficacy of high-dose ascorbate treatment against a variety of tumor entities, including glioblastoma, the most common and...
3.
Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication
Herzog A, Gobel K, Marongiu L, Ruetalo N, Campos Alonso M, Leischner C, et al.
Phytomedicine
. 2023 Nov;
123:155176.
PMID: 37976697
Background: Selected natural compounds exhibit very good antiviral properties. Especially, the medicinal plant Humulus lupulus (hop) contains several secondary plant metabolites some of which have previously shown antiviral activities. Among...
4.
Leischner C, Marongiu L, Piotrowsky A, Niessner H, Venturelli S, Burkard M, et al.
Antioxidants (Basel)
. 2023 Apr;
12(4).
PMID: 37107291
Despite the increasing number of newly diagnosed malignancies worldwide, therapeutic options for some tumor diseases are unfortunately still limited. Interestingly, preclinical but also some clinical data suggest that the administration...
5.
Burkard M, Niessner H, Leischner C, Piotrowsky A, Renner O, Marongiu L, et al.
Cells
. 2023 Jan;
12(2).
PMID: 36672190
Ascorbate acts as a prooxidant when administered parenterally at high supraphysiological doses, which results in the generation of hydrogen peroxide in dependence on oxygen. Most cancer cells are susceptible to...
6.
Sinnberg T, Lichtensteiger C, Hill-Mundel K, Leischner C, Niessner H, Busch C, et al.
Antioxidants (Basel)
. 2022 Aug;
11(8).
PMID: 36009299
Coronavirus disease 2019 (COVID-19) is the most notable pandemic of the modern era. A relationship between ascorbate (vitamin C) and COVID-19 severity is well known, whereas the role of other...
7.
Mayer M, Berger A, Leischner C, Renner O, Burkard M, Bocker A, et al.
Pharmaceuticals (Basel)
. 2022 Apr;
15(4).
PMID: 35455435
Gossypol, a sesquiterpenoid found in cotton seeds, exerts anticancer effects on several tumor entities due to inhibition of DNA synthesis and other mechanisms. In clinical oncology, histone deacetylase inhibitors (HDACi)...
8.
Niessner H, Burkard M, Leischner C, Renner O, Ploger S, Meraz-Torres F, et al.
Cells
. 2022 Apr;
11(7).
PMID: 35406796
High-dose ascorbate paradoxically acts as a pro-oxidant causing the formation of hydrogen peroxide in an oxygen dependent manner. Tumor cells (in particular melanoma cells) show an increased vulnerability to ascorbate...
9.
Venturelli S, Leischner C, Helling T, Renner O, Burkard M, Marongiu L
Cancers (Basel)
. 2022 Mar;
14(5).
PMID: 35267564
Cancer is the second leading cause of death worldwide and is expected to increase by one-third over the next two decades, in parallel with the growing proportion of the elderly...
10.
Renner O, Mayer M, Leischner C, Burkard M, Berger A, Lauer U, et al.
Pharmaceuticals (Basel)
. 2022 Feb;
15(2).
PMID: 35215257
The potential of gossypol and of its R-(-)-enantiomer (R-(-)-gossypol acetic acid, AT-101), has been evaluated for treatment of cancer as an independent agent and in combination with standard chemo-radiation-therapies, respectively....