Christian LeGuern
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Explore the profile of Christian LeGuern including associated specialties, affiliations and a list of published articles.
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28
Citations
233
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Recent Articles
1.
Efe O, Gassen R, Morena L, Ganchiku Y, Al Jurdi A, Lape I, et al.
J Clin Invest
. 2024 Mar;
134(5).
PMID: 38426492
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system...
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3.
Zhai N, Liu W, Jin C, Ding Y, Sun L, Zhang D, et al.
J Immunol
. 2023 Jul;
211(5):885-894.
PMID: 37486211
IFN-γ is a pleiotropic cytokine that plays a controversial role in regulatory T cell (Treg) activity. In this study, we sought to understand how IFN-γ receptor (IFN-γR) signaling affects donor...
4.
Poznansky S, Yu M, Deng K, Fu Q, Markmann J, LeGuern C
Front Immunol
. 2023 May;
14:1173672.
PMID: 37180165
A subset of B-cells with tolerogenic functions, termed B-regulatory cells or Bregs, is characterized by the expression of anti-inflammatory/tolerogenic cytokines, namely IL-10, TGF-β, and IL-35, that contribute to their regulatory...
5.
Lee K, Fu Q, Huai G, Deng K, Lei J, Kojima L, et al.
JCI Insight
. 2022 Aug;
7(17).
PMID: 35943811
B lymphocytes have long been recognized for their critical contributions to adaptive immunity, providing defense against pathogens through cognate antigen presentation to T cells and Ab production. More recently appreciated...
6.
Dwyer L, Stowe A, Doyle K, Popovich P, Engler-Chiurazzi E, LeGuern C, et al.
FASEB J
. 2022 Jul;
36(8):e22459.
PMID: 35857314
No abstract available.
7.
Matheson R, Deng K, Huai G, Lee K, Feeney N, Coe T, et al.
Transplant Rev (Orlando)
. 2021 Dec;
36(1):100674.
PMID: 34861509
Transplantation of xenogeneic organs is an attractive solution to the existing organ shortage dilemma, thus, securing a clinically acceptable prolongation of xenograft survival is an important goal. In preclinical transplantation...
8.
Fu Q, Lee K, Huai G, Deng K, Agarwal D, Rickert C, et al.
Am J Transplant
. 2021 Jul;
21(12):3847-3857.
PMID: 34327838
Regulatory B cells (Bregs) have shown promise as anti-rejection therapy applied to organ transplantation. However, less is known about their effect on other B cell populations that are involved in...
9.
Tanimine N, Burrell B, Deng K, Rickert C, Lee K, Feeney N, et al.
J Immunol Methods
. 2021 Feb;
491:112987.
PMID: 33556344
Precise analyses of alloreactive T cell phenotype and function can inform both the nature and intensity of adaptive responses to transplant antigens. However, alloreactive T cells are sparse and difficult...
10.
LeGuern C, Germana S
Am J Transplant
. 2018 Nov;
19(1):15-20.
PMID: 30378738
Therapies using thymus-derived regulatory T cells (Tregs) are promising strategies for preventing autoimmunity or graft rejection. The efficacy of these approaches is, however, contingent on a better understanding of Treg...