Christian Harcken
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Explore the profile of Christian Harcken including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
259
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Recent Articles
1.
Harcken C, Csengery J, Turner M, Wu L, Liang S, Sibley R, et al.
ACS Med Chem Lett
. 2021 Jan;
12(1):143-154.
PMID: 33488976
The interleukin (IL)-23/T helper (Th)17 axis plays a critical role in autoimmune diseases, and there is an increasing number of biologic therapies that target IL-23 and IL-17. The transcription factor...
2.
Litzenburger T, Steffgen J, Benediktus E, Muller F, Schultz A, Klein E, et al.
Br J Clin Pharmacol
. 2020 Sep;
87(4):1824-1838.
PMID: 32986868
Aims: To evaluate the safety, pharmacokinetics and pharmacodynamics of single- and multiple-rising doses (MRDs) of BI 705564 and establish proof of mechanism. Methods: BI 705564 was studied in 2 placebo-controlled,...
3.
Harcken C, Scholl P, Nabozny G, Thomson D, Bianchi D
Expert Opin Investig Drugs
. 2019 Mar;
28(5):489-496.
PMID: 30908082
Background: An efficacious anti-inflammatory corticosteroid with reduced side effects has been long sought. We report the pooled results from three clinical proof-of-mechanism Phase I studies of BI 653048 in healthy...
4.
Venken K, Jacques P, Mortier C, Labadia M, Decruy T, Coudenys J, et al.
Nat Commun
. 2019 Jan;
10(1):9.
PMID: 30602780
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). RORγt, the key Thelper17 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like...
5.
Harcken C, Kuzmich D, Cook B, Mao C, Disalvo D, Razavi H, et al.
Bioorg Med Chem Lett
. 2019 Jan;
29(3):441-448.
PMID: 30595446
Exploring various cyclization strategies, using a submicromolar pyrazole HTS screening hit 6 as a starting point, a novel indazole based CCR1 antagonist core was discovered. This report presents the design...
6.
Harcken C, Sarko C, Mao C, Lord J, Raudenbush B, Razavi H, et al.
Bioorg Med Chem Lett
. 2018 Nov;
29(3):435-440.
PMID: 30455146
A HTS screen for CCR1 antagonists afforded a novel sub-micromolar hit 5 containing a pyrazole core. In this report the design, optimization, and SAR of novel CCR1 antagonists based on...
7.
Bassolas-Molina H, Raymond E, Labadia M, Wahle J, Ferrer-Picon E, Panzenbeck M, et al.
Front Immunol
. 2018 Nov;
9:2307.
PMID: 30405600
Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan receptor gamma (RORγt), the master...
8.
Chalmers S, Glynn E, Garcia S, Panzenbeck M, Pelletier J, Dimock J, et al.
Clin Immunol
. 2018 Oct;
197:205-218.
PMID: 30339790
Lupus nephritis is a common disease manifestation of SLE, in which immune complex deposition and macrophage activation are important contributors to disease pathogenesis. Bruton's tyrosine kinase (BTK) plays an important...
9.
Bartko J, Derhaschnig U, Neels T, Nabozny G, Harcken C, Leuschner J, et al.
Pharmacol Res
. 2017 Sep;
125(Pt B):215-223.
PMID: 28923543
Selective glucocorticoid receptor modulators (GRMs) promise to reduce adverse events of glucocorticoids while maintaining anti-inflammatory potency. The present study tested the anti-inflammatory activity of two novel non-steroidal GRMs (GRM1: BI...
10.
Chalmers S, Doerner J, Bosanac T, Khalil S, Smith D, Harcken C, et al.
Sci Rep
. 2016 May;
6:26164.
PMID: 27192942
Lupus nephritis (LN) is a potentially dangerous end organ pathology that affects upwards of 60% of lupus patients. Bruton's tyrosine kinase (BTK) is important for B cell development, Fc receptor...