Christian H Ottensmeier
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Explore the profile of Christian H Ottensmeier including associated specialties, affiliations and a list of published articles.
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101
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10724
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Recent Articles
11.
Hanley C, Waise S, Ellis M, Lopez M, Pun W, Taylor J, et al.
Nat Commun
. 2023 Jan;
14(1):387.
PMID: 36720863
Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we use single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry (CIBERSORTx) to identify and characterise three major fibroblast subpopulations...
12.
Eschweiler S, Wang A, Ramirez-Suastegui C, von Witzleben A, Li Y, Chee S, et al.
Cell Rep
. 2023 Jan;
42(2):112040.
PMID: 36701231
Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer immunotherapy target in mice, its potential to...
13.
Gan C, Lee B, Lau S, Kallarakkal T, Zaini Z, Lye B, et al.
Front Immunol
. 2022 Sep;
13:954567.
PMID: 36119104
Oral potentially malignant disorders (OPMD) are precursors of oral squamous cell carcinoma (OSCC), and the presence of oral epithelial dysplasia (OED) in OPMD confers an increased risk of malignant transformation....
14.
Pandori W, Padgett L, Alimadadi A, Gutierrez N, Araujo D, Huh C, et al.
J Leukoc Biol
. 2022 Jul;
112(5):1053-1063.
PMID: 35866369
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can result in severe immune dysfunction, hospitalization, and death. Many patients also develop long-COVID-19, experiencing symptoms...
15.
Eschweiler S, Ramirez-Suastegui C, Li Y, King E, Chudley L, Thomas J, et al.
Nature
. 2022 May;
605(7911):741-746.
PMID: 35508656
Phosphoinositide 3-kinase δ (PI3Kδ) has a key role in lymphocytes, and inhibitors that target this PI3K have been approved for treatment of B cell malignancies. Although studies in mouse models...
16.
Olingy C, Alimadadi A, Araujo D, Barry D, Gutierrez N, Werbin M, et al.
Front Immunol
. 2022 May;
13:842653.
PMID: 35493454
Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related deaths globally. Immune checkpoint blockade (ICB) has transformed cancer medicine, with anti-programmed cell death protein 1 (anti-PD-1) therapy now...
17.
Doescher J, von Witzleben A, Boukas K, Weissinger S, Thomas G, Laban S, et al.
Front Oncol
. 2022 Apr;
12:862694.
PMID: 35433484
Chemoradiotherapy (CRT) is a standard treatment for advanced head and neck squamous cell carcinoma (HNSCC). Unfortunately, not all patients respond to this therapy and require further treatment, either salvage surgery...
18.
Hussain K, Liu R, Smith R, Muller K, Ghorbani M, Macari S, et al.
J Exp Clin Cancer Res
. 2022 Apr;
41(1):131.
PMID: 35392965
Background: Hypoxia is a hallmark of the tumor microenvironment (TME) and in addition to altering metabolism in cancer cells, it transforms tumor-associated stromal cells. Within the tumor stromal cell compartment,...
19.
Naheed S, Holden C, Tanno L, Pattini L, Pearce N, Green B, et al.
BMJ Open
. 2022 Mar;
12(3):e041961.
PMID: 35241462
Objectives: Ki-67, a marker of cellular proliferation, is associated with prognosis across a wide range of tumours, including gastroenteropancreatic neuroendocrine neoplasms (NENs), lymphoma, urothelial tumours and breast carcinomas. Its omission...
20.
Schmiedel B, Rocha J, Gonzalez-Colin C, Bhattacharyya S, Madrigal A, Ottensmeier C, et al.
Nat Commun
. 2021 Nov;
12(1):6760.
PMID: 34799557
Common genetic polymorphisms associated with COVID-19 illness can be utilized for discovering molecular pathways and cell types driving disease pathogenesis. Given the importance of immune cells in the pathogenesis of...