Christian Behrends
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Explore the profile of Christian Behrends including associated specialties, affiliations and a list of published articles.
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102
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10103
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Recent Articles
1.
Zein L, Dietrich M, Balta D, Bader V, Scheuer C, Zellner S, et al.
Autophagy
. 2025 Jan;
1-21.
PMID: 39744815
Lysosomes are the major cellular organelles responsible for nutrient recycling and degradation of cellular material. Maintenance of lysosomal integrity is essential for cellular homeostasis and lysosomal membrane permeabilization (LMP) sensitizes...
2.
Wu J, Kislinger G, Duschek J, Durmaz A, Wefers B, Feng R, et al.
Nat Commun
. 2024 Nov;
15(1):9756.
PMID: 39528474
Oligodendrocytes extend numerous cellular processes that wrap multiple times around axons to generate lipid-rich myelin sheaths. Myelin biogenesis requires an enormously productive biosynthetic machinery for generating and delivering these large...
3.
Mukhopadhyay U, Levantovsky S, Carusone T, Gharbi S, Stein F, Behrends C, et al.
Sci Adv
. 2024 Aug;
10(32):eadp3000.
PMID: 39121224
Over 600 E3 ligases in humans execute ubiquitination of specific target proteins in a spatiotemporal manner to elicit desired signaling effects. Here, we developed a ubiquitin-specific proximity-based labeling method to...
4.
Brenner D, Sieverding K, Srinidhi J, Zellner S, Secker C, Yilmaz R, et al.
J Exp Med
. 2024 Mar;
221(5).
PMID: 38517332
Heterozygous mutations in the TBK1 gene can cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The majority of TBK1-ALS/FTD patients carry deleterious loss-of-expression mutations, and it is still unclear...
5.
Gahlot P, Kravic B, Rota G, Boom J, Levantovsky S, Schulze N, et al.
Mol Cell
. 2024 Mar;
84(8):1556-1569.e10.
PMID: 38503285
Cells respond to lysosomal membrane permeabilization by membrane repair or selective macroautophagy of damaged lysosomes, termed lysophagy, but it is not fully understood how this decision is made. Here, we...
6.
Rogov V, Nezis I, Tsapras P, Zhang H, Dagdas Y, Noda N, et al.
Autophagy Rep
. 2024 Jan;
2(1).
PMID: 38214012
The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8...
7.
Furthmann N, Bader V, Angersbach L, Blusch A, Goel S, Sanchez-Vicente A, et al.
Nat Commun
. 2023 Dec;
14(1):8368.
PMID: 38114471
NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in innate immune signaling, cell death regulation and host-pathogen interactions. Here we identify an NF-κB-independent function of NEMO in...
8.
Nalbach K, Schifferer M, Bhattacharya D, Ho-Xuan H, Tseng W, Williams L, et al.
Nat Commun
. 2023 Dec;
14(1):8322.
PMID: 38097576
No abstract available.
9.
Tian Y, Milic J, Monasor L, Chakraborty R, Wang S, Yuan Y, et al.
Cell Mol Life Sci
. 2023 Aug;
80(9):262.
PMID: 37597109
The constitutive photomorphogenesis 9 (COP9) signalosome (CSN) is a deNEDDylase controlling ubiquitination activity of cullin-RING-E3 ligases (CRLs) and thus the levels of key cellular proteins. While the CSN and its...
10.
Julg J, Edbauer D, Behrends C
EMBO Rep
. 2023 Jun;
24(8):e55895.
PMID: 37317656
Hexanucleotide repeat expansions within C9orf72 are a frequent cause of amyotrophic lateral sclerosis and frontotemporal dementia. Haploinsufficiency leading to reduced C9orf72 protein contributes to disease pathogenesis. C9orf72 binds SMCR8 to...