Chris Yun
Overview
Explore the profile of Chris Yun including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
391
Followers
0
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Recent Articles
1.
Mummery C, Borjesson-Hanson A, Blackburn D, Vijverberg E, De Deyn P, Ducharme S, et al.
Nat Med
. 2023 Oct;
30(1):304.
PMID: 37845513
No abstract available.
2.
Mummery C, Borjesson-Hanson A, Blackburn D, Vijverberg E, De Deyn P, Ducharme S, et al.
Nat Med
. 2023 Apr;
29(6):1437-1447.
PMID: 37095250
Tau plays a key role in Alzheimer's disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with a tau-targeting...
3.
Mignon L, Doan K, Murphy M, Elder L, Yun C, Milton J, et al.
Contemp Clin Trials
. 2022 Jun;
119:106819.
PMID: 35691489
Background: Pharmaceutical drug development rarely addresses a study participant's control of their genomic data, how to return individual incidental findings, and how to make use of genomic data more efficiently...
4.
Timmerberg J, Krosschell K, Dunaway Young S, Uher D, Yun C, Montes J
PLoS One
. 2021 Apr;
16(4):e0249279.
PMID: 33886555
Background And Purpose: With the availability and development of disease-modifying therapies for individuals with spinal muscular atrophy (SMA), new emerging phenotypes must be characterized, and potential new treatment paradigms tested....
5.
Zhao L, Bartnikas T, Chu X, Klein J, Yun C, Srinivasan S, et al.
FASEB J
. 2018 Nov;
33(3):3549-3561.
PMID: 30423260
Excessive iron increases the incidence of diabetes and worsens diabetic complications. Reciprocally, diabetes induces iron loading, partially attributable to elevated intestinal iron export according to a recent report. Herein, we...
6.
Glanzman A, Mazzone E, Dunaway Young S, Gee R, Rose K, Mayhew A, et al.
J Neuromuscul Dis
. 2018 Jun;
5(2):159-166.
PMID: 29865090
Background: Training methodology was established to optimize reliability of outcome measures in the nusinersen clinical trials. The Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND), Hammersmith Functional...
7.
Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, et al.
Pflugers Arch
. 2014 Oct;
467(8):1795-807.
PMID: 25271043
A dysfunction of the Na(+)/H(+) exchanger isoform 3 (NHE3) significantly contributes to the reduced salt absorptive capacity of the inflamed intestine. We previously reported a strong decrease in the NHERF...
8.
Chen M, Sultan A, Cinar A, Yeruva S, Riederer B, Singh A, et al.
J Physiol
. 2010 Oct;
588(Pt 24):5049-63.
PMID: 20962002
Trafficking and regulation of the epithelial brush border membrane (BBM) Na+/H+ exchanger 3 (NHE3) in the intestine involves interaction with four different members of the NHERF family in a signal-dependent...
9.
Singh A, Riederer B, Krabbenhoft A, Rausch B, Bonhagen J, Lehmann U, et al.
J Clin Invest
. 2009 Feb;
119(3):540-50.
PMID: 19221439
The epithelial anion channel CFTR interacts with multiple PDZ domain-containing proteins. Heterologous expression studies have demonstrated that the Na+/H+ exchanger regulatory factors, NHERF1, NHERF2, and PDZK1 (NHERF3), modulate CFTR membrane...
10.
Hillesheim J, Riederer B, Tuo B, Chen M, Manns M, Biber J, et al.
Pflugers Arch
. 2007 Mar;
454(4):575-86.
PMID: 17347851
The PDZ-binding protein PDZK1 (CAP70/PDZ-dc-1/NHERF3) in vitro binds to cystic fibrosis transmembrane conductance regulator (CFTR), the anion exchangers SLC26A3 and SLC26A6 and the Na(+)/H(+) exchanger NHE3, all of which are...