Chris Wallace
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Explore the profile of Chris Wallace including associated specialties, affiliations and a list of published articles.
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Articles
125
Citations
13093
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Recent Articles
11.
Willis T, Wallace C
PLoS Genet
. 2023 Aug;
19(8):e1010852.
PMID: 37585442
Assessment of the genetic similarity between two phenotypes can provide insight into a common genetic aetiology and inform the use of pleiotropy-informed, cross-phenotype analytical methods to identify novel genetic associations....
12.
Vigorito E, Barton A, Pitzalis C, Lewis M, Wallace C
Bioinformatics
. 2023 Jun;
39(7).
PMID: 37338536
Motivation: While many pipelines have been developed for calling genotypes using RNA-sequencing (RNA-Seq) data, they all have adapted DNA genotype callers that do not model biases specific to RNA-Seq such...
13.
Sanderson E, Glymour M, Holmes M, Kang H, Morrison J, Munafo M, et al.
Nat Rev Methods Primers
. 2023 Jun;
2.
PMID: 37325194
Mendelian randomization (MR) is a term that applies to the use of genetic variation to address causal questions about how modifiable exposures influence different outcomes. The principles of MR are...
14.
Wallace C, Gordon M, Sinopoulou V, Akobeng A
Cochrane Database Syst Rev
. 2023 Feb;
2:CD012849.
PMID: 36799531
Background: Functional abdominal pain is pain occurring in the abdomen that cannot be fully explained by another medical condition and is common in children. It has been hypothesised that the...
15.
16.
Hutchinson A, Liley J, Wallace C
BMC Bioinformatics
. 2022 Jul;
23(1):310.
PMID: 35907789
Background: Genome-wide association studies (GWAS) are limited in power to detect associations that exceed the stringent genome-wide significance threshold. This limitation can be alleviated by leveraging relevant auxiliary data, such...
17.
Coleman S, Kirk P, Wallace C
BMC Bioinformatics
. 2022 Jul;
23(1):290.
PMID: 35864476
Background: Cluster analysis is an integral part of precision medicine and systems biology, used to define groups of patients or biomolecules. Consensus clustering is an ensemble approach that is widely...
18.
Sumner E, Almeida B, Palman J, Bale P, Heard C, Holzinger D, et al.
Clin Rheumatol
. 2022 Apr;
41(9):2825-2830.
PMID: 35486225
The objective of this study was to determine the effectiveness of MRP8/14 as a predictor of disease flare in patients with juvenile idiopathic arthritis (JIA) following the withdrawal of methotrexate...
19.
Zuber V, Grinberg N, Gill D, Manipur I, Slob E, Patel A, et al.
Am J Hum Genet
. 2022 Apr;
109(5):767-782.
PMID: 35452592
Mendelian randomization and colocalization are two statistical approaches that can be applied to summarized data from genome-wide association studies (GWASs) to understand relationships between traits and diseases. However, despite similarities...
20.
Wallace C, Sinopoulou V, Gordon M, Akobeng A, Llanos-Chea A, Hungria G, et al.
Cochrane Database Syst Rev
. 2022 Mar;
3:CD014257.
PMID: 35349168
Background: Functional constipation is defined as chronic constipation with no identifiable underlying cause. It is a significant cause of morbidity in children, accounting for up to 25% of visits to...