Chris R Kennedy
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Explore the profile of Chris R Kennedy including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
209
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Recent Articles
1.
Jha J, Dai A, Garzarella J, Charlton A, Urner S, Ostergaard J, et al.
Diabetes
. 2022 Mar;
71(6):1282-1298.
PMID: 35275988
Excessive production of renal reactive oxygen species (ROS) plays a major role in diabetic kidney disease (DKD). Here, we provide key findings demonstrating the predominant pathological role of the pro-oxidant...
2.
Diehl K, Hofmeister E, Keys D, Kennedy C
Am J Vet Res
. 2022 Jan;
83(4):349-355.
PMID: 35092667
Objective: To compare single and triplicate applanation tonometry values across previous intraocular pressure (IOP) studies in dogs. Animals: 116 ophthalmologically normal dogs. Procedures: Triplicate IOP readings (n = 1432) from...
3.
Jha J, Dai A, Holterman C, Cooper M, Touyz R, Kennedy C, et al.
Diabetologia
. 2019 Jun;
62(9):1712-1726.
PMID: 31222503
Aims/hypothesis: Excessive production of reactive oxygen species (ROS) plays a detrimental role in the progression of diabetic kidney disease (DKD). Renal oxidative stress activates proinflammatory cytokines, chemokines and profibrotic factors...
4.
Boisvert N, Holterman C, Thibodeau J, Nasrallah R, Kamto E, Comin C, et al.
Clin Sci (Lond)
. 2018 May;
132(13):1453-1470.
PMID: 29739827
Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. deletion in mice leads to progressive axonal degeneration, affecting the dorsal...
5.
Boisvert N, Holterman C, Gutsol A, Coulombe J, Pan W, Alexander R, et al.
Am J Physiol Renal Physiol
. 2018 Apr;
315(2):F353-F363.
PMID: 29667913
Loss of ubiquitin COOH-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme required for neuronal function, led to hyperphosphatemia accompanied by phosphaturia in mice, while calcium homeostasis remained intact. We therefore investigated...
6.
Jha J, Banal C, Okabe J, Gray S, Hettige T, Chow B, et al.
Diabetes
. 2017 Jul;
66(10):2691-2703.
PMID: 28747378
NADPH oxidase-derived excessive production of reactive oxygen species (ROS) in the kidney plays a key role in mediating renal injury in diabetes. Pathological changes in diabetes include mesangial expansion and...
7.
Drapeau N, Lizotte F, Denhez B, Guay A, Kennedy C, Geraldes P
Am J Physiol Endocrinol Metab
. 2013 Mar;
304(11):E1188-98.
PMID: 23531619
Renal podocyte apoptosis is an early event of diabetic nephropathy progression. Insulin action is critical for podocyte survival. Previous studies demonstrated that Src homology-2 domain-containing phosphatase-1 (SHP-1) is elevated in...
8.
Sedeek M, Hebert R, Kennedy C, Burns K, Touyz R
Curr Opin Nephrol Hypertens
. 2009 May;
18(2):122-7.
PMID: 19430333
Purpose Of Review: Molecular mechanisms contributing to the pathoetiology of hypertension are complex, involving many interacting systems such as signaling through G protein-coupled receptors, the renin-angiotensin system, vascular inflammation and...