Chris J Howard
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Explore the profile of Chris J Howard including associated specialties, affiliations and a list of published articles.
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24
Citations
378
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Recent Articles
1.
Hope J, Khalid H, Thom M, Howard C, Shaw D
Pathogens
. 2023 Jun;
12(6).
PMID: 37375479
, the causative agent of bovine tuberculosis (bTB), is a globally prevalent pathogen with significant animal welfare, economic and public health impacts. In the UK, the control of bTB relies...
2.
Njongmeta L, Bray J, Davies C, Davis W, Howard C, Hope J, et al.
Vaccine
. 2012 Jan;
30(9):1624-35.
PMID: 22240344
Dendritic cell antigen targeting primes robust immune responses in mouse models. Optimizing this immunization strategy in the actual hosts that require protection will advance development of efficacious contemporary vaccines. In...
3.
Graham E, Thom M, Howard C, Boysen P, Storset A, Sopp P, et al.
Vet Immunol Immunopathol
. 2009 Jun;
132(2-4):101-8.
PMID: 19525013
Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity...
4.
Endsley J, Waters W, Palmer M, Nonnecke B, Thacker T, Jacobs Jr W, et al.
Vet Immunol Immunopathol
. 2008 Nov;
128(1-3):199-204.
PMID: 19027175
Tuberculosis (TB) remains a major threat to public health. The identification of safe TB vaccine candidates beyond Mycobacterium bovis BCG, is an exciting prospect for control of human TB and...
5.
Hope J, Howard C, Prentice H, Charleston B
Nat Protoc
. 2007 Apr;
1(2):982-7.
PMID: 17406334
Dendritic cells (DCs) are central to the induction of immune responses and are a pivotal control point that determines the outcome of infectious challenge. Cannulation of afferent lymphatic vessels allows...
6.
Widdison S, Ashley G, Howard C, Coffey T
Vet Immunol Immunopathol
. 2007 Mar;
117(3-4):302-9.
PMID: 17336395
Inducible nitric oxide (iNOS) is an enzyme that catalyzes the production of the reactive nitrogen intermediate nitric oxide (NO). NO is an important signalling molecule, released by numerous cells, that...
7.
Mwangi W, Brown W, Splitter G, Davies C, Howard C, Hope J, et al.
Clin Vaccine Immunol
. 2007 Jan;
14(3):304-11.
PMID: 17215335
We developed a vaccine construct in which a BVP22 domain and an invariant-chain major histocompatibility complex class II-targeting motif capable of enhancing dendritic cell antigen uptake and presentation were fused...
8.
Harris J, Schwinn N, Mahoney J, Lin H, Shaw M, Howard C, et al.
Int J Exp Pathol
. 2006 Jan;
87(1):29-39.
PMID: 16436111
Carboxypeptidase, vitellogenic-like (CPVL) is a serine carboxypeptidase of unknown function that was first characterized in human macrophages. Initial studies suggested that CPVL is largely restricted to the monocytic lineage, although...
9.
van den Berg T, van Beek E, Buhring H, Colonna M, Hamaguchi M, Howard C, et al.
J Immunol
. 2005 Dec;
175(12):7788-9.
PMID: 16339511
No abstract available.
10.
Abbott J, Palmer G, Kegerreis K, Hetrick P, Howard C, Hope J, et al.
J Immunol
. 2005 May;
174(11):6702-15.
PMID: 15905510
In humans and ruminants infected with Anaplasma, the major surface protein 2 (MSP2) is immunodominant. Numerous CD4(+) T cell epitopes in the hypervariable and conserved regions of MSP2 contribute to...