Chris Hoffmann
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Explore the profile of Chris Hoffmann including associated specialties, affiliations and a list of published articles.
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12
Citations
53
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Recent Articles
1.
Hoffmann C, Endepols H, Urusova E, Elchine D, Neumaier F, Neumaier B, et al.
Eur J Med Chem
. 2025 Jan;
286:117265.
PMID: 39826488
Serotonergic 5-HT receptors in the cortex and other forebrain structures have been linked to cognitive, emotional and memory processes. In addition, dysfunction or altered expression of these receptors is associated...
2.
Hoffmann C, Krasemann S, Wurr S, Hartmann K, Adam E, Bockholt S, et al.
Nat Commun
. 2024 Oct;
15(1):9319.
PMID: 39472431
Lassa virus (LASV) outbreaks in West Africa pose a significant public health threat. We investigated the infection phenotype and transmission (horizontal and vertical) of LASV strain Ba366 in its natural...
3.
Groner B, Hoffmann C, Endepols H, Urusova E, Brugger M, Neumaier F, et al.
Mol Pharm
. 2024 May;
21(6):2795-2812.
PMID: 38747353
-([F]Fluoroethyl)-l-tyrosine ([F]FET) is actively transported into the brain and cancer cells by LAT1 and possibly other amino acid transporters, which enables brain tumor imaging by positron emission tomography (PET). However,...
4.
Humpert S, Hoffmann C, Neumaier F, Zlatopolskiy B, Neumaier B
J Chromatogr B Analyt Technol Biomed Life Sci
. 2023 Aug;
1228:123847.
PMID: 37634390
Accurate assessment of isolated radiochemical yields (RCYs) is a prerequisite for efficient and reliable optimization of labeling reactions. In practice, radiochemical conversions (RCCs) determined by HPLC analysis of crude reaction...
5.
Hoffmann C, Kolks N, Smets D, Haseloer A, Groner B, Urusova E, et al.
Chemistry
. 2022 Oct;
29(2):e202202965.
PMID: 36214204
Cu-mediated radiofluorination is a versatile tool for the preparation of F-labeled (hetero)aromatics. In this work, we systematically evaluated a series of complexes and identified several generally applicable mediators for highly...
6.
Brinkmann N, Hoffmann C, Wurr S, Pallasch E, Hinzmann J, Ostermann E, et al.
Viruses
. 2022 Sep;
14(9).
PMID: 36146793
is the natural host of various arenaviruses, including the human-pathogenic Lassa virus. Homologous arenaviruses, defined here as those having as a natural host, can establish long-lasting infection in while these...
7.
Soubrier H, Bangura U, Hoffmann C, Olayemi A, Adesina A, Gunther S, et al.
Viruses
. 2022 May;
14(5).
PMID: 35632733
The aim of this study was to evaluate the use of a capture enzyme-linked immunosorbent assay (ELISA) for the detection of LASV-reactive IgG antibodies in rodents. The assay was used...
8.
Kramer F, Groner B, Hoffmann C, Craig A, Brugger M, Drzezga A, et al.
Cancers (Basel)
. 2021 Dec;
13(23).
PMID: 34885141
Purpose: The preclinical evaluation of 3-l- and 3-d-[F]FPhe in comparison to [F]FET, an established tracer for tumor imaging. Methods: In vitro studies were conducted with MCF-7, PC-3, and U87 MG...
9.
Hoffmann C, Evcuman S, Neumaier F, Zlatopolskiy B, Humpert S, Bier D, et al.
ACS Chem Neurosci
. 2021 Aug;
12(18):3335-3346.
PMID: 34449193
Selective inhibition of glycine transporter 1 (GlyT1) has emerged as a potential approach to alleviate -methyl-d-aspartate receptor (NMDAR) hypofunction in patients with schizophrenia and cognitive decline. ALX5407 is a potent...
10.
Olschewski S, Thielebein A, Hoffmann C, Blake O, Muller J, Bockholt S, et al.
Viruses
. 2021 Jun;
13(6).
PMID: 34073735
Several of the human-pathogenic arenaviruses cause hemorrhagic fever and have to be handled under biosafety level 4 conditions, including Lassa virus. Rapid and safe inactivation of specimens containing these viruses...