Chou-Wei Chang
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Explore the profile of Chou-Wei Chang including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
321
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0
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Recent Articles
1.
Dai Y, Yeh S, Cheng Y, Huang W, Liou G, Yang T, et al.
J Virol
. 2024 Jan;
98(2):e0189923.
PMID: 38294245
After Epstein-Barr virus (EBV) genome replication and encapsidation in the nucleus, nucleocapsids are translocated into the cytoplasm for subsequent tegumentation and maturation. The EBV BGLF4 kinase, which induces partial disassembly...
2.
Xu X, Chang C, Li M, Omabe K, Le N, Chen Y, et al.
Nat Commun
. 2023 Mar;
14(1):1233.
PMID: 36871012
Deletion of the conserved C-terminus of the Rothmund-Thomson syndrome helicase RECQ4 is highly tumorigenic. However, while the RECQ4 N-terminus is known to facilitate DNA replication initiation, the function of its...
3.
Chang C, Singh A, Li M, Guan L, Le N, Omabe K, et al.
Proc Natl Acad Sci U S A
. 2022 Dec;
119(50):e2217542119.
PMID: 36490315
R-loops, or RNA:DNA hybrids, can induce DNA damage, which requires DNA repair factors including breast cancer type 1 susceptibility protein (BRCA1) to restore genomic integrity. To date, several pathogenic mutations...
4.
Xu X, Chang C, Li M, Liu C, Liu Y
Front Mol Biosci
. 2021 Dec;
8:791194.
PMID: 34869606
The human gene encodes an ATP-dependent DNA helicase that contains a conserved superfamily II helicase domain located at the center of the polypeptide. RECQ4 is one of the five RECQ...
5.
Pathogenic mutations reveal a role of RECQ4 in mitochondrial RNA:DNA hybrid formation and resolution
Chang C, Xu X, Li M, Xin D, Ding L, Wang Y, et al.
Sci Rep
. 2020 Oct;
10(1):17033.
PMID: 33046774
The synthesis of mitochondrial DNA (mtDNA) is a complex process that involves the formation and resolution of unusual nucleic acid structures, such as RNA:DNA hybrids. However, little is known about...
6.
Li M, Xu X, Chang C, Liu Y
Proc Natl Acad Sci U S A
. 2020 Sep;
117(38):23588-23596.
PMID: 32900933
In human cells, the DNA replication factor proliferating cell nuclear antigen (PCNA) can be conjugated to either the small ubiquitinlike modifier SUMO1 or SUMO2, but only SUMO2-conjugated PCNA is induced...
7.
Prahlad J, Yuan Y, Lin J, Chang C, Iwata-Reuyl D, Liu Y, et al.
J Biol Chem
. 2020 Aug;
295(41):14236-14247.
PMID: 32796037
DUF328 family proteins are present in many prokaryotes; however, their molecular activities are unknown. The DUF328 protein YaaA is a member of the OxyR regulon and is protective against oxidative...
8.
Li M, Xu X, Chang C, Zheng L, Shen B, Liu Y
Nat Commun
. 2018 Jul;
9(1):2706.
PMID: 30006506
During DNA synthesis, DNA replication and transcription machinery can collide, and the replication fork may temporarily dislodge RNA polymerase II (RNAPII) to resolve the transcription-replication conflict (TRC), a major source...
9.
Wang Y, Chen J, Chang C, Jen J, Huang T, Chen C, et al.
J Clin Invest
. 2017 Jul;
127(8):2982-2997.
PMID: 28691927
The tumor microenvironment plays an important role in tumor growth and metastasis. However, the mechanism by which tumor cells regulate the cell and non-cell constituents of surrounding stroma remains incompletely...
10.
Lee C, Liu G, Kung H, Liu P, Liao Y, Chow L, et al.
J Virol
. 2016 Jul;
90(20):8994-9007.
PMID: 27466427
Unlabelled: The cellular endosomal sorting complex required for transport (ESCRT) was recently found to mediate important morphogenesis processes at the nuclear envelope (NE). We previously showed that the Epstein-Barr virus...