Choi-Lai Tiong-Yip
Overview
Explore the profile of Choi-Lai Tiong-Yip including associated specialties, affiliations and a list of published articles.
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5
Citations
87
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Recent Articles
1.
Tria G, Abrams T, Baird J, Burks H, Firestone B, Gaither L, et al.
J Med Chem
. 2018 Mar;
61(7):2837-2864.
PMID: 29562737
In breast cancer, estrogen receptor alpha (ERα) positive cancer accounts for approximately 74% of all diagnoses, and in these settings, it is a primary driver of cell proliferation. Treatment of...
2.
Plant H, Stacey C, Tiong-Yip C, Walsh J, Yu Q, Rich K
J Biomol Screen
. 2015 Feb;
20(5):597-605.
PMID: 25656237
Respiratory syncytial virus (RSV) infects 99% of children by age 2 years and is a leading cause of serious lower respiratory tract infection (LRTI) and infant hospitalization in the United...
3.
Tiong-Yip C, Aschenbrenner L, Johnson K, McLaughlin R, Fan J, Challa S, et al.
Antimicrob Agents Chemother
. 2014 Apr;
58(7):3867-73.
PMID: 24777090
The respiratory syncytial virus (RSV) L protein is a viral RNA-dependent RNA polymerase that contains multiple enzyme activities required for RSV replication. The RSV L inhibitors described in literature are...
4.
Tiong-Yip C, Plant H, Sharpe P, Fan J, Rich K, Gorseth E, et al.
Antiviral Res
. 2013 Nov;
101:75-81.
PMID: 24246168
Respiratory syncytial virus (RSV) drug discovery has been hindered by the lack of good chemistry starting points and would benefit from robust and convenient assays for high-throughput screening (HTS). In...
5.
Xiong H, Foulk M, Aschenbrenner L, Fan J, Tiong-Yip C, Johnson K, et al.
Bioorg Med Chem Lett
. 2013 Nov;
23(24):6789-93.
PMID: 24211022
Targeting viral polymerases has been a proven and attractive strategy for antiviral drug discovery. Herein we describe our effort in improving the antiviral activity and physical properties of a series...