Chiranjeev Sharma
Overview
Explore the profile of Chiranjeev Sharma including associated specialties, affiliations and a list of published articles.
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13
Citations
96
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Recent Articles
1.
Sharma C, Hamza A, Boyle E, Donu D, Cen Y
Biomolecules
. 2024 Mar;
14(3).
PMID: 38540730
Diabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for...
2.
Sharma C, Donu D, Curry A, Barton E, Cen Y
RSC Adv
. 2023 Apr;
13(17):11771-11781.
PMID: 37063743
The sirtuin family of NAD-dependent protein deacylases has gained significant attention during the last two decades, owing to their unique enzymatic activities as well as their critical roles in a...
3.
Singh P, Sharma C, Sharma B, Mishra A, Agarwal D, Kannan D, et al.
Eur J Med Chem
. 2022 Oct;
244:114774.
PMID: 36306538
The artemisinin resistance has posed a serious threat against malaria elimination lately. Past few years have seen important development of several peroxide based medicinal compounds and their derivatives such as...
4.
Sharma C, Donu D, Cen Y
Nutrients
. 2022 Oct;
14(19).
PMID: 36235542
Among all the NAD precursors, nicotinamide riboside (NR) has gained the most attention as a potent NAD-enhancement agent. This recently discovered vitamin, B3, has demonstrated excellent safety and efficacy profiles...
5.
Donu D, Sharma C, Cen Y
Biomolecules
. 2022 Aug;
12(8).
PMID: 36009002
Inhibition of nicotinamidase could represent a potential antimalarial since parasites require nicotinic acid to successfully recycle nicotinamide to NAD, and importantly, humans lack this biosynthetic enzyme. Recently, mechanism-based inhibitors of...
6.
Lee T, Kim J, Kwon S, Seo J, Park S, Kim J, et al.
J Med Chem
. 2022 Mar;
65(7):5751-5759.
PMID: 35319890
Immunoglobulin Gs (IgGs) contain many Lys and Cys residues, which results in an unwanted complex product mixture with conventional drug conjugation methods. We selectively acylated the ε-NH of K248 on...
7.
Sharma C, Choi M, Song Y, Seo Y
Molecules
. 2022 Mar;
27(5).
PMID: 35268755
PROTACs employ the proteosome-mediated proteolysis via E3 ligase and recruit the natural protein degradation machinery to selectively degrade the cancerous proteins. Herein, we have designed and synthesized heterobifunctional small molecules...
8.
Sharma C, Kim Y, Ahn D, Chung S
Arch Pharm Res
. 2021 Feb;
44(3):310-321.
PMID: 33590390
Protein tyrosine phosphatases (PTPs) have an emerging paradigm for the development of antidiabetic drugs. Herein, we provide a comprehensive overview of the relevance of PTPs to type 2 diabetes (T2D)...
9.
Yadav P, Sharma B, Sharma C, Singh P, Awasthi S
ACS Omega
. 2020 Apr;
5(12):6472-6480.
PMID: 32258882
Dispiro-tetraoxanes, a class of fully synthetic peroxides which can be used as an antiplasmodial remedy for multiple drug-resistant strains of , were selected for the interaction study with human serum...
10.
Sharma C, Oh Y, Park B, Lee S, Jeong C, Lee S, et al.
Int J Mol Sci
. 2019 Dec;
20(24).
PMID: 31835389
Thiazolidinedione is a five-membered heterocycle that is widely used in drug discovery endeavors. In this study, we report the design, synthesis, and biological evaluation of a series of thiazolidinedione-based HDAC6...