Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 2019 Jun 16

PMID 31201237

Citations 9

Authors

Viveka Mayya

Edward Judokusumo

Enas Abu-Shah

Willie Neiswanger

Chirag Sachar

David Depoil

Lance C Kam

Michael L Dustin

Affiliations

Soon will be listed here.

Abstract

Memory T cells are endowed with multiple functional features that enable them to be more protective than naive T cells against infectious threats. It is not known if memory cells have a higher synapse propensity (SP; i.e., increased probability to form immature immunological synapses that then provide an entry into different modes of durable interaction with APCs). In this study, we show that only human memory CD8 T cells have remarkably high SP compared with naive counterparts. Such a dichotomy between naive and memory cells is not observed within the human CD4 or murine CD8 T cell population. Higher SP in human memory CD8 T cells allows them to outcompete and prevent naive CD8 T cells from getting recruited to the response. This observation has implications for original antigenic sin and aging of the immune system in humans.

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