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Chirag Krishna

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Articles 29
Citations 1641
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Recent Articles
1.
Dikiy S, Ghelani A, Levine A, Martis S, Giovanelli P, Wang Z, et al.
Nat Immunol . 2025 Feb; 26(3):444-458. PMID: 39905200
Regulatory T (T) cells are a specialized CD4 T cell lineage with essential anti-inflammatory functions. Analysis of T cell adaptations to non-lymphoid tissues that enable their specialized immunosuppressive and tissue-supportive...
2.
Alban T, Riaz N, Parthasarathy P, Makarov V, Kendall S, Yoo S, et al.
Nat Med . 2024 Sep; 30(11):3209-3222. PMID: 39349627
Neoantigen immunoediting drives immune checkpoint blockade efficacy, yet the molecular features of neoantigens and how neoantigen immunogenicity shapes treatment response remain poorly understood. To address these questions, 80 patients with...
3.
Krishna C, Chiou J, Sakaue S, Kang J, Christensen S, Lee I, et al.
Nat Commun . 2024 Jul; 15(1):6469. PMID: 39085222
Genetic variation in the human leukocyte antigen (HLA) loci is associated with risk of immune-mediated diseases, but the molecular effects of HLA polymorphism are unclear. Here we examined the effects...
4.
Trsan T, Peng V, Krishna C, Ohara T, Beatty W, Sudan R, et al.
Dev Cell . 2024 Jun; 59(18):2460-2476.e10. PMID: 38942017
Recent advances in human genetics have shed light on the genetic factors contributing to inflammatory diseases, particularly Crohn's disease (CD), a prominent form of inflammatory bowel disease. Certain risk genes...
5.
Zhou W, Cuomo A, Xue A, Kanai M, Chau G, Krishna C, et al.
medRxiv . 2024 May; PMID: 38798318
Understanding the genetic basis of gene expression can help us understand the molecular underpinnings of human traits and disease. Expression quantitative trait locus (eQTL) mapping can help in studying this...
6.
Brandt M, Cao Z, Krishna C, Reedy J, Gu X, Dutko R, et al.
Cell Rep . 2024 Mar; 43(3):113944. PMID: 38489265
Population genetics continues to identify genetic variants associated with diseases of the immune system and offers a unique opportunity to discover mechanisms of immune regulation. Multiple genetic variants linked to...
7.
Krishna C, Tervi A, Saffern M, Wilson E, Yoo S, Mars N, et al.
Science . 2024 Feb; 383(6685):eadi3808. PMID: 38386728
Cancer risk is influenced by inherited mutations, DNA replication errors, and environmental factors. However, the influence of genetic variation in immunosurveillance on cancer risk is not well understood. Leveraging population-level...
8.
Weber J, Morrone J, Kang S, Zhang L, Lang L, Chowell D, et al.
Brief Bioinform . 2024 Jan; 25(1). PMID: 38233090
Immunologic recognition of peptide antigens bound to class I major histocompatibility complex (MHC) molecules is essential to both novel immunotherapeutic development and human health at large. Current methods for predicting...
9.
Kong L, Pokatayev V, Lefkovith A, Carter G, Creasey E, Krishna C, et al.
Immunity . 2023 Dec; 56(12):2855. PMID: 38091954
No abstract available.
10.
Kong L, Pokatayev V, Lefkovith A, Carter G, Creasey E, Krishna C, et al.
Immunity . 2023 Jan; 56(2):444-458.e5. PMID: 36720220
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and environmental factors, necessitating a system-level...