Chirag Krishna
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Explore the profile of Chirag Krishna including associated specialties, affiliations and a list of published articles.
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29
Citations
1641
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Recent Articles
11.
Nixon B, Kuo F, Ji L, Liu M, Capistrano K, Do M, et al.
Immunity
. 2022 Oct;
55(11):2044-2058.e5.
PMID: 36288724
Tumors are populated by antigen-presenting cells (APCs) including macrophage subsets with distinct origins and functions. Here, we examined how cancer impacts mononuclear phagocytic APCs in a murine model of breast...
12.
Kansler E, Dadi S, Krishna C, Nixon B, Stamatiades E, Liu M, et al.
Nat Immunol
. 2022 Jun;
23(8):1285.
PMID: 35705800
No abstract available.
13.
Kansler E, Dadi S, Krishna C, Nixon B, Stamatiades E, Liu M, et al.
Nat Immunol
. 2022 May;
23(6):904-915.
PMID: 35618834
Malignancy can be suppressed by the immune system. However, the classes of immunosurveillance responses and their mode of tumor sensing remain incompletely understood. Here, we show that although clear cell...
14.
Chou C, Zhang X, Krishna C, Nixon B, Dadi S, Capistrano K, et al.
Nature
. 2022 Apr;
605(7908):139-145.
PMID: 35444279
Cellular transformation induces phenotypically diverse populations of tumour-infiltrating T cells, and immune checkpoint blockade therapies preferentially target T cells that recognize cancer cell neoantigens. Yet, how other classes of tumour-infiltrating...
15.
Nixon B, Chou C, Krishna C, Dadi S, Michel A, Cornish A, et al.
Sci Immunol
. 2022 Apr;
7(70):eabi8642.
PMID: 35394814
Innate lymphocytes are integral components of the cellular immune system that can coordinate host defense against a multitude of challenges and trigger immunopathology when dysregulated. Natural killer (NK) cells and...
16.
Krishna C, Hakimi A
Cancer Res
. 2022 Mar;
82(5):764-765.
PMID: 35247895
Immune receptor repertoires provide insight into the clonal distribution of tumor-infiltrating lymphocytes, yet the clinical implications of T-cell receptor (TCR) and B-cell receptor (BCR) repertoire diversity in cancer are unclear....
17.
Vorkas C, Krishna C, Li K, Aube J, Fitzgerald D, Mazutis L, et al.
J Immunol
. 2022 Feb;
208(5):1042-1056.
PMID: 35149530
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize microbial vitamin B metabolites and have emerging roles in infectious disease, autoimmunity, and cancer. Although MAIT cells are identified by...
18.
Chowell D, Yoo S, Valero C, Pastore A, Krishna C, Lee M, et al.
Nat Biotechnol
. 2021 Nov;
40(4):499-506.
PMID: 34725502
Only a fraction of patients with cancer respond to immune checkpoint blockade (ICB) treatment, but current decision-making procedures have limited accuracy. In this study, we developed a machine learning model...
19.
Lee C, DiNatale R, Chowell D, Krishna C, Makarov V, Valero C, et al.
Mol Cancer Res
. 2021 May;
19(9):1510-1521.
PMID: 34039647
Immune checkpoint blockade (ICB) therapy has substantially improved the outcomes of patients with many types of cancers, including renal cell carcinoma (RCC). Initially studied as monotherapy, immunotherapy-based combination regimens have...
20.
Krishna C, DiNatale R, Kuo F, Srivastava R, Vuong L, Chowell D, et al.
Cancer Cell
. 2021 Apr;
39(5):662-677.e6.
PMID: 33861994
Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, but the effect of immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here we perform paired...