Ching-Chieh Tung
Overview
Explore the profile of Ching-Chieh Tung including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
395
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Recent Articles
1.
Zhang J, Singh D, Ko C, Nikolaienko R, Wong King Yuen S, Schwarz J, et al.
J Biol Chem
. 2021 Nov;
298(1):101412.
PMID: 34793835
The N-terminal region (NTR) of ryanodine receptor (RyR) channels is critical for the regulation of Ca release during excitation-contraction (EC) coupling in muscle. The NTR hosts numerous mutations linked to...
2.
Gardill B, Rivera-Acevedo R, Tung C, Van Petegem F
Proc Natl Acad Sci U S A
. 2019 May;
116(22):10763-10772.
PMID: 31072926
Voltage-gated sodium (Na) and calcium channels (Ca) form targets for calmodulin (CaM), which affects channel inactivation properties. A major interaction site for CaM resides in the C-terminal (CT) region, consisting...
3.
Gardill B, Rivera-Acevedo R, Tung C, Okon M, McIntosh L, Van Petegem F
Sci Rep
. 2018 Mar;
8(1):4483.
PMID: 29540853
Voltage-gated sodium channels (Na) are responsible for the rapid depolarization of many excitable cells. They readily inactivate, a process where currents diminish after milliseconds of channel opening. They are also...
4.
Wong King Yuen S, Campiglio M, Tung C, Flucher B, Van Petegem F
Proc Natl Acad Sci U S A
. 2017 Oct;
114(45):E9520-E9528.
PMID: 29078335
Excitation-contraction (EC) coupling in skeletal muscle requires functional and mechanical coupling between L-type voltage-gated calcium channels (Ca1.1) and the ryanodine receptor (RyR1). Recently, STAC3 was identified as an essential protein...
5.
McGregor N, Yin V, Tung C, Van Petegem F, Brumer H
Plant J
. 2016 Nov;
89(4):651-670.
PMID: 27859885
The xyloglucan endotransglycosylase/hydrolase (XTH) gene family encodes enzymes of central importance to plant cell wall remodeling. The evolutionary history of plant XTH gene products is incompletely understood vis-à-vis the larger...
6.
Brath U, Swamy S, Veiga A, Tung C, Van Petegem F, Erdelyi M
J Am Chem Soc
. 2015 Aug;
137(35):11391-8.
PMID: 26289584
Transient biomolecular interactions are the cornerstones of the cellular machinery. The identification of the binding sites for low affinity molecular encounters is essential for the development of high affinity pharmaceuticals...
7.
Kimlicka L, Tung C, Carlsson A, Lobo P, Yuchi Z, Van Petegem F
Structure
. 2013 Jul;
21(8):1440-9.
PMID: 23871484
Ryanodine receptors (RyRs) are calcium release channels located in the membrane of the endoplasmic and sarcoplasmic reticulum and play a major role in muscle excitation-contraction coupling. The cardiac isoform (RyR2)...
8.
Kimlicka L, Lau K, Tung C, Van Petegem F
Nat Commun
. 2013 Feb;
4:1506.
PMID: 23422674
Ryanodine receptors are large channels that release Ca(2+) from the endoplasmic and sarcoplasmic reticulum. Hundreds of RyR mutations can cause cardiac and skeletal muscle disorders, yet detailed mechanisms explaining their...
9.
Sarhan M, Tung C, Van Petegem F, Ahern C
Proc Natl Acad Sci U S A
. 2012 Feb;
109(9):3558-63.
PMID: 22331908
Voltage-gated sodium channels underlie the rapid regenerative upstroke of action potentials and are modulated by cytoplasmic calcium ions through a poorly understood mechanism. We describe the 1.35 Å crystal structure...
10.
Lobo P, Kimlicka L, Tung C, Van Petegem F
Structure
. 2011 Jun;
19(6):790-8.
PMID: 21645850
Mutations in the cardiac Ryanodine Receptor (RYR2) are linked to triggered arrhythmias. Removal of exon 3 results in a severe form of catecholaminergic polymorphic ventricular tachycardia (CPVT). This exon encodes...