Chih-Chieh Jay Yu
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Explore the profile of Chih-Chieh Jay Yu including associated specialties, affiliations and a list of published articles.
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Citations
647
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Recent Articles
1.
Valdes P, Yu C, Aronson J, Ghosh D, Zhao Y, An B, et al.
Sci Transl Med
. 2024 Jan;
16(732):eabo0049.
PMID: 38295184
Proteins are densely packed in cells and tissues, where they form complex nanostructures. Expansion microscopy (ExM) variants have been used to separate proteins from each other in preserved biospecimens, improving...
2.
Gunay K, Chang T, Skillin N, Rao V, Macdougall L, Cutler A, et al.
Nat Mater
. 2023 May;
22(6):777-785.
PMID: 37217701
Hydrogels are extensively used as tunable, biomimetic three-dimensional cell culture matrices, but optically deep, high-resolution images are often difficult to obtain, limiting nanoscale quantification of cell-matrix interactions and outside-in signalling....
3.
Yu C, Orozco Cosio D, Boyden E
Methods Mol Biol
. 2022 Mar;
2468:141-203.
PMID: 35320565
Studies of C. elegans will benefit from a powerful method for super-resolution imaging of proteins and mRNAs at any 3-D locations throughout the entire animal. Conventional methods of super-resolution imaging...
4.
Gao R, Yu C, Gao L, Piatkevich K, Neve R, Munro J, et al.
Nat Nanotechnol
. 2021 Mar;
16(6):698-707.
PMID: 33782587
Expansion microscopy (ExM) physically magnifies biological specimens to enable nanoscale-resolution imaging using conventional microscopes. Current ExM methods permeate specimens with free-radical-chain-growth-polymerized polyacrylate hydrogels, whose network structure limits the local isotropy...
5.
Alon S, Goodwin D, Sinha A, Wassie A, Chen F, Daugharthy E, et al.
Science
. 2021 Jan;
371(6528).
PMID: 33509999
Methods for highly multiplexed RNA imaging are limited in spatial resolution and thus in their ability to localize transcripts to nanoscale and subcellular compartments. We adapt expansion microscopy, which physically...
6.
Linghu C, Johnson S, Valdes P, Shemesh O, Park W, Park D, et al.
Cell
. 2020 Nov;
183(6):1682-1698.e24.
PMID: 33232692
In order to analyze how a signal transduction network converts cellular inputs into cellular outputs, ideally one would measure the dynamics of many signals within the network simultaneously. We found...
7.
Shemesh O, Linghu C, Piatkevich K, Goodwin D, Celiker O, Gritton H, et al.
Neuron
. 2020 Jun;
107(3):470-486.e11.
PMID: 32592656
Methods for one-photon fluorescent imaging of calcium dynamics can capture the activity of hundreds of neurons across large fields of view at a low equipment complexity and cost. In contrast...
8.
Yu C, Barry N, Wassie A, Sinha A, Bhattacharya A, Asano S, et al.
Elife
. 2020 May;
9.
PMID: 32356725
We recently developed expansion microscopy (ExM), which achieves nanoscale-precise imaging of specimens at ~70 nm resolution (with ~4.5x linear expansion) by isotropic swelling of chemically processed, hydrogel-embedded tissue. ExM of...
9.
Tillberg P, Chen F, Piatkevich K, Zhao Y, Yu C, English B, et al.
Nat Biotechnol
. 2016 Jul;
34(9):987-92.
PMID: 27376584
Expansion microscopy (ExM) enables imaging of preserved specimens with nanoscale precision on diffraction-limited instead of specialized super-resolution microscopes. ExM works by physically separating fluorescent probes after anchoring them to a...
10.
Yu C, Raizen D, Fang-Yen C
J Neurosci Methods
. 2013 Dec;
223:35-9.
PMID: 24321627
Background: The nematode Caenorhabditis elegans is widely used as a model for understanding the neuronal and genetic bases of behavior. Recent studies have required longitudinal assessment of individual animal's behavior...