Chi H Trinh
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Explore the profile of Chi H Trinh including associated specialties, affiliations and a list of published articles.
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44
Citations
577
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Recent Articles
1.
Vella M, Manfield I, Seychell B, Trinh C, Rambo R, Nasir Khan G, et al.
Biochimie
. 2024 Sep;
228:114-126.
PMID: 39299536
The aryl hydrocarbon receptor interacting protein (AIP) is a cytoplasmic molecular co-chaperone and tumour suppressor that assists in protein stability and complex formation involving the aryl hydrocarbon receptor. Germline mutations...
2.
Li Y, Trinh C, Acevedo-Jake A, Gimenez D, Warriner S, Wilson A
Biochem J
. 2024 Jun;
481(14):945-955.
PMID: 38899489
The PDZ (Postsynaptic density protein-95[PSD-95]/Discs-large) domain, prevalent as a recognition module, has attracted significant attention given its ability to specifically recognize ligands with consensus motifs (also termed PDZ binding motifs...
3.
Martin H, Turner A, Higgins J, Tang A, Tiede C, Taylor T, et al.
Cell Rep
. 2023 Sep;
42(10):113184.
PMID: 37776520
Kinases are important therapeutic targets, and their inhibitors are classified according to their mechanism of action, which range from blocking ATP binding to covalent inhibition. Here, a mechanism of inhibition...
4.
Srdanovic S, Wolter M, Trinh C, Ottmann C, Warriner S, Wilson A
FEBS J
. 2022 Mar;
289(17):5341-5358.
PMID: 35286747
p53 plays a critical role in regulating diverse biological processes: DNA repair, cell cycle arrest, apoptosis and senescence. The p53 pathway has therefore served as the focus of multiple drug-discovery...
5.
Turner L, Trinh C, Hubball R, Orritt K, Lin C, Burns J, et al.
J Med Chem
. 2021 Nov;
65(2):1481-1504.
PMID: 34780700
Fibroblast growth factor receptors (FGFRs) are implicated in a range of cancers with several pan-kinase and selective-FGFR inhibitors currently being evaluated in clinical trials. Pan-FGFR inhibitors often cause toxic side...
6.
Haza K, Martin H, Rao A, Turner A, Saunders S, Petersen B, et al.
Nat Commun
. 2021 Jul;
12(1):4045.
PMID: 34193876
RAS mutations are the most common oncogenic drivers across human cancers, but there remains a paucity of clinically-validated pharmacological inhibitors of RAS, as druggable pockets have proven difficult to identify....
7.
Hegedus Z, Hobor F, Shoemark D, Celis S, Lian L, Trinh C, et al.
Chem Sci
. 2021 Jun;
12(6):2286-2293.
PMID: 34163995
β-Strand mediated protein-protein interactions (PPIs) represent underexploited targets for chemical probe development despite representing a significant proportion of known and therapeutically relevant PPI targets. β-Strand mimicry is challenging given that...
8.
Bonetta R, Hunter G, Trinh C, Borowski T, Fenech A, Kulp M, et al.
Eur Biophys J
. 2021 May;
50(3-4):571-585.
PMID: 34021366
We have generated a mutant of C. elegans manganese superoxide dismutase at histidine 30 by site-directed mutagenesis. The structure was solved at a resolution of 1.52 Å by X-ray crystallography...
9.
Curd A, Leng J, Hughes R, Cleasby A, Rogers B, Trinh C, et al.
Nano Lett
. 2020 Nov;
21(3):1213-1220.
PMID: 33253583
Inferring the organization of fluorescently labeled nanosized structures from single molecule localization microscopy (SMLM) data, typically obscured by stochastic noise and background, remains challenging. To overcome this, we developed a...
10.
Miles J, Hobor F, Trinh C, Taylor J, Tiede C, Rowell P, et al.
Chembiochem
. 2020 Sep;
22(1):232-240.
PMID: 32961017
The BCL-2 family is a challenging group of proteins to target selectively due to sequence and structural homologies across the family. Selective ligands for the BCL-2 family regulators of apoptosis...