Thomas A Edwards
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Explore the profile of Thomas A Edwards including associated specialties, affiliations and a list of published articles.
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Articles
72
Citations
1420
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Recent Articles
1.
Cawood E, Baker E, Edwards T, Woolfson D, Karamanos T, Wilson A
Chem Sci
. 2024 Jul;
15(26):10237-10245.
PMID: 38966365
A significant challenge in chemical biology is to understand and modulate protein-protein interactions (PPIs). Given that many PPIs involve a folded protein domain and a peptide sequence that is intrinsically...
2.
Passchier T, White J, Maskell D, Byrne M, Ranson N, Edwards T, et al.
Sci Rep
. 2024 Jun;
14(1):14099.
PMID: 38890308
We report the first cryoEM structure of the Hendra henipavirus nucleoprotein in complex with RNA, at 3.5 Å resolution, derived from single particle analysis of a double homotetradecameric RNA-bound N...
3.
Hopkins F, Alvarez-Rodriguez B, Heath G, Panayi K, Hover S, Edwards T, et al.
mBio
. 2022 Jun;
13(4):e0140522.
PMID: 35762594
The order is the largest group of negative-sense RNA viruses, containing many lethal human pathogens for which approved anti-infective measures are not available. The bunyavirus genome consists of multiple negative-sense...
4.
Hobor F, Hegedus Z, Ibarra A, Petrovicz V, Bartlett G, Sessions R, et al.
RSC Chem Biol
. 2022 Jun;
3(5):592-603.
PMID: 35656479
The hypoxic response is central to cell function and plays a significant role in the growth and survival of solid tumours. HIF-1 regulates the hypoxic response by activating over 100...
5.
Mohamad M, Nicholson D, Saha C, Hauryliuk V, Edwards T, Atkinson G, et al.
Nucleic Acids Res
. 2022 Feb;
50(4):2128-2142.
PMID: 35137182
The first member of the pleuromutilin (PLM) class suitable for systemic antibacterial chemotherapy in humans recently entered clinical use, underscoring the need to better understand mechanisms of PLM resistance in...
6.
Hetherington K, Dutt S, Ibarra A, Cawood E, Hobor F, Woolfson D, et al.
RSC Chem Biol
. 2021 Oct;
2(5):1474-1478.
PMID: 34704051
A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein-protein interactions (PPIs) is described.
7.
Haza K, Martin H, Rao A, Turner A, Saunders S, Petersen B, et al.
Nat Commun
. 2021 Jul;
12(1):4045.
PMID: 34193876
RAS mutations are the most common oncogenic drivers across human cancers, but there remains a paucity of clinically-validated pharmacological inhibitors of RAS, as druggable pockets have proven difficult to identify....
8.
Hegedus Z, Hobor F, Shoemark D, Celis S, Lian L, Trinh C, et al.
Chem Sci
. 2021 Jun;
12(6):2286-2293.
PMID: 34163995
β-Strand mediated protein-protein interactions (PPIs) represent underexploited targets for chemical probe development despite representing a significant proportion of known and therapeutically relevant PPI targets. β-Strand mimicry is challenging given that...
9.
Celis S, Hobor F, James T, Bartlett G, Ibarra A, Shoemark D, et al.
Chem Sci
. 2021 Jun;
12(13):4753-4762.
PMID: 34163731
Protein-protein interactions (PPIs) are central to biological mechanisms, and can serve as compelling targets for drug discovery. Yet, the discovery of small molecule inhibitors of PPIs remains challenging given the...
10.
Miles J, Hobor F, Trinh C, Taylor J, Tiede C, Rowell P, et al.
Chembiochem
. 2020 Sep;
22(1):232-240.
PMID: 32961017
The BCL-2 family is a challenging group of proteins to target selectively due to sequence and structural homologies across the family. Selective ligands for the BCL-2 family regulators of apoptosis...