Cheng-Liang Kuo
Overview
Explore the profile of Cheng-Liang Kuo including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
330
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Recent Articles
1.
Kuo C, Lin Y, Lo Y, Lu Y, Babuharisankar A, Lien H, et al.
iScience
. 2024 Sep;
27(9):110710.
PMID: 39262792
Mitochondria play important roles in cell fate, calcium signaling, mitophagy, and the signaling through reactive oxygen species (ROS). Recently, mitochondria are considered as a signaling organelle in the cell and...
2.
Babuharisankar A, Kuo C, Chou H, Tangeda V, Fan C, Chen C, et al.
Cell Death Dis
. 2023 Mar;
14(3):199.
PMID: 36927870
During hypoxia, FUNDC1 acts as a mitophagy receptor and accumulates at the ER (endoplasmic reticulum)-mitochondria contact sites (EMC), also called mitochondria-associated membranes (MAM). In mitophagy, the ULK1 complex phosphorylates FUNDC1(S17)...
3.
Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?
Kuo C, Babuharisankar A, Lin Y, Lien H, Lo Y, Chou H, et al.
J Biomed Sci
. 2022 Sep;
29(1):74.
PMID: 36154922
The major concept of "oxidative stress" is an excess elevated level of reactive oxygen species (ROS) which are generated from vigorous metabolism and consumption of oxygen. The precise harmonization of...
4.
Kuo C, Chou H, Lien H, Yeh C, Wang J, Chen C, et al.
Cancer Immunol Immunother
. 2022 Jul;
72(2):351-369.
PMID: 35895109
Background: Immunotherapy is an emerging cancer therapy with potential great success; however, immune checkpoint inhibitor (e.g., anti-PD-1) has response rates of only 10-30% in solid tumor because of the immunosuppressive...
5.
Tangeda V, Lo Y, Babuharisankar A, Chou H, Kuo C, Kao Y, et al.
Cell Death Dis
. 2022 Mar;
13(3):241.
PMID: 35296653
Mitochondria are the major organelles in sensing cellular stress and inducing the response for cell survival. Mitochondrial Lon has been identified as an important stress protein involved in regulating proliferation,...
6.
Cheng A, Cheng L, Kuo C, Lo Y, Chou H, Chen C, et al.
J Immunother Cancer
. 2020 Dec;
8(2).
PMID: 33268351
Background: Mitochondrial Lon is a chaperone and DNA-binding protein that functions in protein quality control and stress response pathways. The level of Lon regulates mitochondrial DNA (mtDNA) metabolism and the...
7.
Kuo C, Chou H, Chiu Y, Cheng A, Fan C, Chang Y, et al.
Cancer Lett
. 2020 Jan;
474:138-150.
PMID: 31987921
Mitochondrial Lon is a chaperone protein whose upregulation increases the production of mitochondrial reactive oxygen species (ROS). However, there is a lack of information in detail on how mitochondrial Lon...
8.
Fan C, Chen C, Chou C, Kao T, Cheng A, Lee A, et al.
J Clin Lab Anal
. 2019 Nov;
34(4):e23110.
PMID: 31733007
Background: Despite having chronic gastritis, most people infected by Helicobacter pylori (H. pylori) are asymptomatic and have no specific clinical signs and symptoms. H. pylori infection can be diagnosed by...
9.
Sung Y, Kao T, Kuo C, Fan C, Cheng A, Fang W, et al.
Cell Death Dis
. 2018 Jun;
9(6):697.
PMID: 29899330
Mitochondrial Lon is a multi-function matrix protease with chaperone activity. However, little literature has been undertaken into detailed investigations on how Lon regulates apoptosis through its chaperone activity. Accumulating evidences...
10.
Cheng A, Fan C, Lo Y, Kuo C, Wang H, Lien I, et al.
Sci Rep
. 2017 Dec;
7(1):17024.
PMID: 29209046
Cdc7-Dbf4 kinase plays a key role in the initiation of DNA replication and contributes to the replication stress in cancer. The activity of human Cdc7-Dbf4 kinase remains active and acts...