Cheng-Kun Du
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Explore the profile of Cheng-Kun Du including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
347
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Recent Articles
1.
Pearson J, Thambyah H, Waddingham M, Inagaki T, Sukumaran V, Ngo J, et al.
Clin Sci (Lond)
. 2021 Jan;
135(2):327-346.
PMID: 33480422
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been...
2.
Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf E, et al.
JACC Basic Transl Sci
. 2020 Dec;
5(11):1057-1069.
PMID: 33294739
The treatment of pediatric heart failure is a long-standing unmet medical need. Angiotensin II supports mammalian perinatal circulation by activating cardiac L-type Ca channels through angiotensin type 1 receptor (ATR)...
3.
Pearson J, Shirai M, Sukumaran V, Du C, Tsuchimochi H, Sonobe T, et al.
Vasc Biol
. 2020 Sep;
1(1):H97-H102.
PMID: 32923960
Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin...
4.
Lew J, Pearson J, Saw E, Tsuchimochi H, Wei M, Ghosh N, et al.
Circ Res
. 2020 Sep;
127(11):1384-1400.
PMID: 32907486
Rationale: Diabetic heart disease (DHD) is a debilitating manifestation of type 2 diabetes mellitus. Exercise has been proposed as a potential therapy for DHD, although the effectiveness of exercise in...
5.
Sonobe T, Akiyama T, Du C, Pearson J
Physiol Rep
. 2019 Nov;
7(22):e14297.
PMID: 31782271
Serotonin (5-HT) accumulates in the heart during myocardial ischemia and induces deleterious effects on the cardiomyocytes through receptor-dependent and monoamine oxidase-dependent pathways. We aimed to clarify the involvement of extra-neuronal...
6.
Katare R, Pearson J, Lew J, Wei M, Tsuchimouchi H, Du C, et al.
Front Physiol
. 2018 Jun;
9:696.
PMID: 29928236
The causal factors underpinning the onset and progression of diabetic heart disease (DHD) remain to be fully elucidated. Myocardial function is critically dependent on optimal coronary blood flow. Considering vascular...
7.
Arimura T, Muchir A, Kuwahara M, Morimoto S, Ishikawa T, Du C, et al.
Am J Physiol Heart Circ Physiol
. 2018 Feb;
314(6):H1192-H1202.
PMID: 29451818
Mutations in genes encoding components of the sarcomere cause cardiomyopathy, which is often associated with abnormal Ca sensitivity of muscle contraction. We have previously shown that a heart-specific myosin light...
8.
Zhan D, Du C, Akiyama T, Morimoto S, Shimizu S, Kawada T, et al.
Auton Neurosci
. 2017 Mar;
205:33-40.
PMID: 28344023
The aim of this study was to evaluate cardiac vagal nerve activity and identify the abnormality of cardiac vagal control in heart failure caused by dilated cardiomyopathy (DCM) using a...
9.
Du C, Zhan D, Akiyama T, Inagaki T, Shishido T, Shirai M, et al.
Am J Physiol Heart Circ Physiol
. 2016 Oct;
312(1):H60-H67.
PMID: 27793854
New & Noteworthy: By monitoring myocardial interstitial levels of 5-HT and its metabolite, 5-hydroxyindole acetic acid, we investigated 5-HT kinetics during myocardial ischemia-reperfusion. 5-HT accumulates but 5-HT degradation is suppressed...
10.
Mohamed R, Morimoto S, Ibrahim I, Zhan D, Du C, Arioka M, et al.
Am J Physiol Heart Circ Physiol
. 2016 Apr;
310(11):H1808-15.
PMID: 27106044
Glycogen synthase kinase-3β (GSK-3β) plays a central role in both cardiac physiology and pathology. Herein we want to clarify the role of GSK-3β in familial dilated cardiomyopathy. We generated a...