Chen-Lin Hsieh
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Explore the profile of Chen-Lin Hsieh including associated specialties, affiliations and a list of published articles.
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16
Citations
637
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Recent Articles
1.
Oliva M, Sarkar M, March M, Saeidian A, Mentch F, Hsieh C, et al.
medRxiv
. 2024 Jul;
PMID: 38946956
Atopic dermatitis (AD) is a highly heritable and common inflammatory skin condition affecting children and adults worldwide. Multi-ancestry approaches to AD genetic association studies are poised to boost power to...
2.
Barlan K, Bhide G, White D, Lake M, Lu C, Rieder S, et al.
SLAS Discov
. 2023 Oct;
29(1):52-58.
PMID: 37844762
N-linked glycosylation is a common post-translational modification that has various effects on multiple types of proteins. The extent to which an N-linked glycoprotein is modified and the identity of glycans...
3.
Yang M, Lee J, Zhang Z, de la Rosa R, Bi M, Tan Y, et al.
Cell Rep
. 2020 Jun;
31(12):107803.
PMID: 32579929
The function of enhancer RNAs (eRNAs) in transcriptional regulation remains obscure. By analyzing the genome-wide nascent transcript profiles in breast cancer cells, we identify a special group of eRNAs that...
4.
Slivka P, Hsieh C, Lipovsky A, Pratt S, Locklear J, Namovic M, et al.
ACS Chem Biol
. 2019 Apr;
14(5):857-872.
PMID: 30938974
Interleukin-17A (IL17A) plays a critical role in the development of numerous autoimmune diseases, including psoriasis. The clinical success of IL17A neutralizing biologics in psoriasis has underlined its importance as a...
5.
Gui B, Hsieh C, Kantoff P, Kibel A, Jia L
PLoS One
. 2017 Sep;
12(9):e0184166.
PMID: 28886115
MicroRNAs (miRNAs) play important roles in cancer formation and progression by suppressing the production of key functional proteins at the post-transcriptional level in a sequence-specific manner. While differential expression of...
6.
Zhou J, Gao S, Hsieh C, Malla M, Shemshedini L
PLoS One
. 2017 Sep;
12(8):e0184088.
PMID: 28859127
Among androgen-regulated genes, soluble guanylyl cyclase α1 (sGCα1) is significant in promoting the survival and growth of prostate cancer cells and does so independent of nitric oxide (NO) signaling. Peptides...
7.
Hsieh C, Botta G, Gao S, Li T, Van Allen E, Treacy D, et al.
Cancer Res
. 2015 Mar;
75(10):1944-8.
PMID: 25808865
Whole-exome sequencing of metastatic castration-resistant prostate cancer (mCRPC) reveals that 5% to 7% of tumors harbor promyelocytic leukemia zinc finger (PLZF) protein homozygous deletions. PLZF is a canonical androgen-regulated putative...
8.
Hsieh C, Fei T, Chen Y, Li T, Gao Y, Wang X, et al.
Proc Natl Acad Sci U S A
. 2014 Apr;
111(20):7319-24.
PMID: 24778216
The androgen receptor (AR) is a key factor that regulates the behavior and fate of prostate cancer cells. The AR-regulated network is activated when AR binds enhancer elements and modulates...
9.
Gao S, Hsieh C, Zhou J, Shemshedini L
PLoS One
. 2013 Nov;
8(11):e78766.
PMID: 24236047
The Zinc Finger (ZNF) 280B protein was identified as an unexpected target of an shRNA designed for sGCα1. Further analysis showed that these two proteins are connected in another way,...
10.
Gao S, Hsieh C, Bhansali M, Kannan A, Shemshedini L
PLoS One
. 2013 Jun;
8(5):e64189.
PMID: 23724033
Among the many identified androgen-regulated genes, sGCα1 (soluble guanylyl cyclase α1) appears to play a pivotal role in mediating the pro-cancer effects of androgens and androgen receptor. The classical role...