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Chee Pang Ng

Explore the profile of Chee Pang Ng including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 90
Followers 0
Related Specialties
Oncology
Biochemistry
Molecular Biology
Top 10 Co-Authors
Hung Huynh
Choon Kiat Ong
Caine Leong
Chuan Young Ng
Wai Chung Ong
Weiping Deng
Kay Lin Goh
Evelyn Tan
Noah Tu
Anders Poulsen
Published In
J Biol Chem
Oncogene
Bioorg Med Chem Lett
Oncol Rep
Endocrinology
Affiliations
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Recent Articles
1.
Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors
Blanchard S, William A, Lee A, Poulsen A, Teo E, Deng W, et al.
Bioorg Med Chem Lett . 2010 Mar; 20(8):2443-7. PMID: 20338758
A series of alkenyl indazoles were synthesized and evaluated in Aurora kinase enzyme assays. Several promising leads were optimized for selectivity towards Aurora B. Excellent binding affinity and good selectivity...
2.
Structure-based design of Aurora A & B inhibitors
Poulsen A, William A, Lee A, Blanchard S, Teo E, Deng W, et al.
J Comput Aided Mol Des . 2008 Jun; 22(12):897-906. PMID: 18574696
The Aurora family of serine/threonine kinases are mitotic regulators involved in centrosome duplication, formation of the bipolar mitotic spindle and the alignment of the chromosomes along the spindle. These proteins...
3.
Structural characterization of three novel rat OKL38 transcripts, their tissue distributions, and their regulation by human chorionic gonadotropin
Ong C, Ng C, Leong C, Ng C, Ong C, Nguyen T, et al.
Endocrinology . 2004 Jun; 145(10):4763-74. PMID: 15217983
We previously identified a novel pregnancy-induced growth inhibitory gene, OKL38. To develop a rat model for further characterization of OKL38's role in the initiation and progression of breast and ovarian...
4.
Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44
Leong C, Ng C, Ong C, Ng C, Ma Z, Nguyen T, et al.
Oncogene . 2004 Jun; 23(33):5707-18. PMID: 15184879
We have previously reported the characterization of an estrogen-regulated rat uterine-ovarian-specific complementary DNA (UO-44). To understand the involvement of this protein in the initiation and progression of human ovarian and...
5.
Reduction of CWR22 prostate tumor xenograft growth by combined tamoxifen-quercetin treatment is associated with inhibition of angiogenesis and cellular proliferation
Ma Z, Hoa Huynh T, Ng C, Tien Do P, Nguyen T, Huynh H
Int J Oncol . 2004 Apr; 24(5):1297-304. PMID: 15067354
Combination chemotherapy is increasingly practiced for the treatment of malignant prostate cancers. The aim of this study was to evaluate the in vivo efficacy of combined tamoxifen and quercetin in...
6.
Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions
Ong C, Tran E, Nguyen T, Ong C, Lee S, Lee J, et al.
Oncol Rep . 2004 Feb; 11(3):727-33. PMID: 14767529
Nasopharyngeal carcinoma is a common cancer in South-East Asia, especially among people of Chinese origin. In this report, we investigate the effects of quercetin on the growth of wild-type and...
7.
Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis
Ong C, Ng C, Leong C, Ng C, Foo K, Tan P, et al.
J Biol Chem . 2003 Oct; 279(1):743-54. PMID: 14570898
We previously demonstrated the growth inhibitory property of OKL38 and its possible roles in mammary carcinogenesis. To further understand the regulation and roles of OKL38 in tumorigenesis we proceeded to...