Rejani B Kunjamma
Overview
Explore the profile of Rejani B Kunjamma including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
762
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0
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Recent Articles
1.
Chen Y, Quan S, Patil V, Kunjamma R, Tokars H, Leisten E, et al.
Glia
. 2023 May;
71(9):2180-2195.
PMID: 37203250
central nervous system (CNS) inflammation triggers activation of the integrated stress response (ISR). We previously reported that prolonging the ISR protects remyelinating oligodendrocytes and promotes remyelination in the presence of...
2.
Chen Y, Quan S, Patil V, Kunjamma R, Tokars H, Leisten E, et al.
bioRxiv
. 2023 Feb;
PMID: 36747743
CNS inflammation triggers activation of the integrated stress response (ISR). We previously reported that prolonging the ISR protects remyelinating oligodendrocytes and promotes remyelination in the presence of inflammation (Chen et...
3.
Chen Y, Kunjamma R, Weiner M, Chan J, Popko B
Elife
. 2021 Mar;
10.
PMID: 33752802
The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether...
4.
Xu H, Dzhashiashvili Y, Shah A, Kunjamma R, Weng Y, Elbaz B, et al.
Neuron
. 2020 Jan;
105(2):293-309.e5.
PMID: 31901304
The molecular mechanisms that govern the maturation of oligodendrocyte lineage cells remain unclear. Emerging studies have shown that N-methyladenosine (mA), the most common internal RNA modification of mammalian mRNA, plays...
5.
Werneburg S, Jung J, Kunjamma R, Ha S, Luciano N, Willis C, et al.
Immunity
. 2019 Dec;
52(1):167-182.e7.
PMID: 31883839
Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on myelin and axon loss in MS, less is known about mechanisms underlying...
6.
Dzhashiashvili Y, Monckton C, Shah H, Kunjamma R, Popko B
Neurobiol Dis
. 2019 Mar;
127:527-544.
PMID: 30923003
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, characterized by motor neuron death in the brain and spinal cord. Mutations in the Cu/Zn superoxide dismutase (SOD1) gene account for...
7.
Chen Y, Podojil J, Kunjamma R, Jones J, Weiner M, Lin W, et al.
Brain
. 2019 Jan;
142(2):344-361.
PMID: 30657878
Multiple sclerosis is a chronic autoimmune demyelinating disorder of the CNS. Immune-mediated oligodendrocyte cell loss contributes to multiple sclerosis pathogenesis, such that oligodendrocyte-protective strategies represent a promising therapeutic approach. The...
8.
Clayton B, Huang A, Kunjamma R, Solanki A, Popko B
J Neurosci
. 2017 Jul;
37(31):7465-7480.
PMID: 28720571
Currently no treatments exist for preterm infants with diffuse white matter injury (DWMI) caused by hypoxia. Due to the improved care of preterm neonates and increased recognition by advanced imaging...
9.
Elbaz B, Traka M, Kunjamma R, Dukala D, Brosius Lutz A, Anton E, et al.
Development
. 2016 May;
143(13):2356-66.
PMID: 27226321
The tumor suppressor protein adenomatous polyposis coli (APC) is multifunctional - it participates in the canonical Wnt/β-catenin signal transduction pathway as well as modulating cytoskeleton function. Although APC is expressed...
10.
Way S, Podojil J, Clayton B, Zaremba A, Collins T, Kunjamma R, et al.
Nat Commun
. 2015 Mar;
6:6532.
PMID: 25766071
Oligodendrocyte death contributes to the pathogenesis of the inflammatory demyelinating disease multiple sclerosis (MS). Nevertheless, current MS therapies are mainly immunomodulatory and have demonstrated limited ability to inhibit MS progression....