Charlotte R Knudsen
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Explore the profile of Charlotte R Knudsen including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
414
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Recent Articles
1.
Birkmose N, Frydendahl E, Knudsen C
Biochemistry
. 2024 Dec;
63(24):3273-3286.
PMID: 39642937
DNA-encoded libraries hold great potential for discovering small, cyclized peptides with drug potential. Split-intein circular ligation of peptides and proteins (SICLOPPS) is a well-established method for selection of cyclic peptides...
2.
Negrutskii B, Porubleva L, Malinowska A, Novosylna O, Dadlez M, Knudsen C
Adv Protein Chem Struct Biol
. 2024 Jan;
138:67-99.
PMID: 38220433
Mammalian translation elongation factors eEF1A1 and eEF1A2 are 92% homologous isoforms whose mutually exclusive tissue-specific expression is regulated during development. The isoforms have similar translation functionality, but show differences in...
3.
Johansen J, Kavaliauskas D, Pfeil S, Blaise M, Cooperman B, Goldman Y, et al.
Nucleic Acids Res
. 2018 Aug;
46(16):8641-8650.
PMID: 30107565
According to the traditional view, GTPases act as molecular switches, which cycle between distinct 'on' and 'off' conformations bound to GTP and GDP, respectively. Translation elongation factor EF-Tu is a...
4.
Kavaliauskas D, Chen C, Liu W, Cooperman B, Goldman Y, Knudsen C
Nucleic Acids Res
. 2018 Aug;
46(16):8651-8661.
PMID: 30107527
The GTPase elongation factor EF-Tu delivers aminoacyl-tRNAs to the mRNA-programmed ribosome during translation. Cognate codon-anticodon interaction stimulates GTP hydrolysis within EF-Tu. It has been proposed that EF-Tu undergoes a large...
5.
Dyla M, Andersen J, Kjaergaard M, Birkedal V, Terry D, Altman R, et al.
Bioconjug Chem
. 2016 Aug;
27(9):2176-87.
PMID: 27501274
Approximately 30% of the ATP generated in the living cell is utilized by P-type ATPase primary active transporters to generate and maintain electrochemical gradients across biological membranes. P-type ATPases undergo...
6.
Gytz H, Mohr D, Seweryn P, Yoshimura Y, Kutlubaeva Z, Dolman F, et al.
Nucleic Acids Res
. 2015 Nov;
43(22):10893-906.
PMID: 26578560
Upon infection of Escherichia coli by bacteriophage Qβ, the virus-encoded β-subunit recruits host translation elongation factors EF-Tu and EF-Ts and ribosomal protein S1 to form the Qβ replicase holoenzyme complex,...
7.
Liu W, Chen C, Kavaliauskas D, Knudsen C, Goldman Y, Cooperman B
Nucleic Acids Res
. 2015 Sep;
43(19):9519-28.
PMID: 26338772
The G-protein EF-Tu, which undergoes a major conformational change when EF-Tu·GTP is converted to EF-Tu·GDP, forms part of an aminoacyl(aa)-tRNA·EF-Tu·GTP ternary complex (TC) that accelerates the binding of aa-tRNA to...
8.
Thirup S, Van L, Nielsen T, Knudsen C
J Struct Biol
. 2015 Jun;
191(1):10-21.
PMID: 26073967
Translation elongation factor EF-Tu belongs to the superfamily of guanine-nucleotide binding proteins, which play key cellular roles as regulatory switches. All G-proteins require activation via exchange of GDP for GTP...
9.
Liu W, Kavaliauskas D, Schrader J, Poruri K, Birkedal V, Goldman E, et al.
ACS Chem Biol
. 2014 Aug;
9(10):2421-31.
PMID: 25126896
The universally conserved translation elongation factor EF-Tu delivers aminoacyl(aa)-tRNA in the form of an aa-tRNA·EF-Tu·GTP ternary complex (TC) to the ribosome where it binds to the cognate mRNA codon within...
10.
Dahl L, Corydon T, Rankel L, Nielsen K, Fuchtbauer E, Knudsen C
Cancer Cell Int
. 2014 Feb;
14(1):17.
PMID: 24571548
Background: The oncogene PTI-1 was originally isolated from a prostate cancer cell line by its capability to transform rat fibroblasts. The PTI-1 mRNA has a very eccentric structure as the...