Charlotte E Egan
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Explore the profile of Charlotte E Egan including associated specialties, affiliations and a list of published articles.
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22
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1356
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Recent Articles
1.
Nino D, Sodhi C, Egan C, Zhou Q, Lin J, Lu P, et al.
Shock
. 2016 Aug;
47(1):22-32.
PMID: 27488085
Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal disease of the premature infant. We have recently shown that NEC development occurs after an increase in proinflammatory CD4Th17 (Th17) cells and...
2.
Cunningham K, Vincent G, Sodhi C, Novak E, Ranganathan S, Egan C, et al.
J Biol Chem
. 2016 Mar;
291(19):10184-200.
PMID: 26969166
Peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α) is the primary regulator of mitochondrial biogenesis and was recently found to be highly expressed within the intestinal epithelium. PGC1α is decreased in the...
3.
Egan C, Sodhi C, Good M, Lin J, Jia H, Yamaguchi Y, et al.
J Clin Invest
. 2015 Dec;
126(2):495-508.
PMID: 26690704
The nature and role of the intestinal leukocytes in necrotizing enterocolitis (NEC), a severe disease affecting premature infants, remain unknown. We now show that the intestine in mouse and human...
4.
Afrazi A, Branca M, Sodhi C, Good M, Yamaguchi Y, Egan C, et al.
J Biol Chem
. 2014 Feb;
289(14):9584-99.
PMID: 24519940
The cellular cues that regulate the apoptosis of intestinal stem cells (ISCs) remain incompletely understood, yet may play a role in diseases characterized by ISC loss including necrotizing enterocolitis (NEC)....
5.
Walker C, Hautefort I, Dalton J, Overweg K, Egan C, Bongaerts R, et al.
PLoS One
. 2013 Dec;
8(12):e84553.
PMID: 24358364
Antimicrobial proteins influence intestinal microbial ecology and limit proliferation of pathogens, yet the regulation of their expression has only been partially elucidated. Here, we have identified a putative pathway involving...
6.
Cohen S, Maurer K, Egan C, Oghumu S, Satoskar A, Denkers E
PLoS Pathog
. 2013 Oct;
9(10):e1003706.
PMID: 24130498
Chemokines and their receptors play a critical role in orchestrating immunity to microbial pathogens, including the orally acquired Th1-inducing protozoan parasite Toxoplasma gondii. Chemokine receptor CXCR3 is associated with Th1...
7.
Egan C, Daugherity E, Rogers A, Abi Abdallah D, Denkers E, Maurer K
PLoS One
. 2013 Jun;
8(6):e65247.
PMID: 23762326
Non-alcoholic fatty liver disease (NAFLD) is a common disease with a spectrum of presentations. The current study utilized a lithogenic diet model of NAFLD. The diet was fed to mice...
8.
Yazji I, Sodhi C, Lee E, Good M, Egan C, Afrazi A, et al.
Proc Natl Acad Sci U S A
. 2013 May;
110(23):9451-6.
PMID: 23650378
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by severe intestinal necrosis and for which breast milk represents the most effective protective strategy. Previous studies have revealed...
9.
Mahamed D, Mills J, Egan C, Denkers E, Bynoe M
Proc Natl Acad Sci U S A
. 2012 Sep;
109(40):16312-7.
PMID: 22988118
Toxoplasma gondii is an obligate intracellular protozoan pathogen that traffics to the central nervous system (CNS) following invasion of its host. In the CNS, T. gondii undergoes transformation from a...
10.
Neal M, Sodhi C, Jia H, Dyer M, Egan C, Yazji I, et al.
J Biol Chem
. 2012 Sep;
287(44):37296-308.
PMID: 22955282
Factors regulating the proliferation and apoptosis of intestinal stem cells (ISCs) remain incompletely understood. Because ISCs exist among microbial ligands, immune receptors such as toll-like receptor 4 (TLR4) could play...