Charles M Conway
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Explore the profile of Charles M Conway including associated specialties, affiliations and a list of published articles.
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28
Citations
530
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Recent Articles
11.
Lipton R, Croop R, Stock E, Stock D, Morris B, Frost M, et al.
N Engl J Med
. 2019 Jul;
381(2):142-149.
PMID: 31291516
Background: Calcitonin gene-related peptide receptor has been implicated in the pathogenesis of migraine. Rimegepant is an orally administered, small-molecule, calcitonin gene-related peptide receptor antagonist that may be effective in acute...
12.
Luo G, Chen L, Conway C, Kostich W, Johnson B, Ng A, et al.
J Org Chem
. 2017 Mar;
82(7):3710-3720.
PMID: 28306261
An asymmetric synthesis of the major metabolite of the calcitonin gene-related peptide recepotor antagonist BMS-846372 is presented. The variously substituted cyclohepta[b]pyridine ring system represents an underexplored ring system and showed...
13.
Takazawa T, Choudhury P, Tong C, Conway C, Scherrer G, Flood P, et al.
J Neurosci
. 2017 Jan;
37(9):2336-2348.
PMID: 28130358
The superficial dorsal horn is the synaptic termination site for many peripheral sensory fibers of the somatosensory system. A wide range of sensory modalities are represented by these fibers, including...
14.
Kostich W, Hamman B, Li Y, Naidu S, Dandapani K, Feng J, et al.
J Pharmacol Exp Ther
. 2016 Jul;
358(3):371-86.
PMID: 27411717
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a...
15.
Civiello R, Han X, Beno B, Chaturvedula P, Herbst J, Xu C, et al.
Bioorg Med Chem Lett
. 2016 Feb;
26(4):1229-32.
PMID: 26832218
Calcitonin gene-related peptide (CGRP) is a potent neuropeptide implicated in the pathophysiology of migraine. In the course of seeking CGRP antagonists with improved oral bioavailability, metabolic stability, and pharmacokinetic properties,...
16.
Luo G, Chen L, Conway C, Kostich W, Macor J, Dubowchik G
Org Lett
. 2015 Dec;
17(24):5982-5.
PMID: 26650258
An asymmetric synthesis of novel heterocyclic analogue of the CGRP receptor antagonist rimegepant (BMS-927711, 3) is reported. The cycloheptane ring was constructed by an intramolecular Heck reaction. The application of...
17.
Luo G, Chen L, Conway C, Denton R, Keavy D, Gulianello M, et al.
ACS Med Chem Lett
. 2014 Jun;
3(4):337-41.
PMID: 24900474
Calcitonin gene-related peptide (CGRP) receptor antagonists have been clinically shown to be effective in the treatment of migraine, but identification of potent and orally bioavailable compounds has been challenging. Herein,...
18.
Wu Y, Conway C, Sun L, Machet F, Chen J, Chen P, et al.
Bioorg Med Chem Lett
. 2013 Sep;
23(22):6188-91.
PMID: 24070783
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful...
19.
Tora G, Degnan A, Conway C, Kostich W, Davis C, Pin S, et al.
Bioorg Med Chem Lett
. 2013 Sep;
23(20):5684-8.
PMID: 23993336
Several new potent CGRP receptor antagonists have been prepared in which the amide bond of lead compound 1 has been replaced by bioisosteric imidazole moieties. Substitution at N-1 of the...
20.
Han X, Civiello R, Conway C, Cook D, Davis C, Degnan A, et al.
Bioorg Med Chem Lett
. 2013 Feb;
23(6):1870-3.
PMID: 23402880
Various substituted indazole and benzoxazolone amino acids were investigated as d-tyrosine surrogates in highly potent CGRP receptor antagonists. Compound 3, derived from the 7-methylindazole core, afforded a 30-fold increase in...